Cerebral Oxygenation in Preterm Infants With Necrotizing Enterocolitis
- 1 September 2020
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in PEDIATRICS
- Vol. 146 (3)
- https://doi.org/10.1542/peds.2020-0337
Abstract
Video Abstract BACKGROUND AND OBJECTIVES: Preterm infants with necrotizing enterocolitis (NEC) are known to have worse neurodevelopmental outcomes, but there is no substantial evidence to support an underlying pathophysiology. We aimed to examine whether cerebral oxygenation differs in those infants who develop NEC compared to cerebral oxygenation in those who do not. METHODS: We examined 48 infants RESULTS: The median birth weight was 884 g (range of 460–1600 g), the median weeks’ gestational age was 26 + 3/7 (23 + 0/7 to 29 + 6/7), and 52% were girls. In total, 276 NIRS measurements were completed, and 7 infants developed NEC. NIRS measurements from 1 infant with NEC and 4 infants without NEC who developed hemorrhagic parenchymal infarcts were excluded from analysis. Infants who developed NEC had significantly lower cerebral tissue oxygenation index than those who did not (P = .011), even when adjusted for confounders, including gestational age, birth weight, patent ductus arteriosus, enteral feeds, sex, ethnicity, and hemoglobin. CONCLUSIONS: Infants with NEC have significantly lower cerebral tissue oxygenation throughout their neonatal intensive care stay in comparison with those who did not develop NEC. This is a novel finding and could explain their worse neurodevelopmental outcome.This publication has 48 references indexed in Scilit:
- Near-Infrared Spectroscopy Assessment of Cerebral Oxygen Metabolism in the Developing Premature BrainJournal of Cerebral Blood Flow & Metabolism, 2011
- The Relationship Between Cerebral Oxygen Saturation Changes and Postoperative Cognitive Dysfunction in Elderly Patients After Coronary Artery Bypass Graft SurgeryJournal of Cardiothoracic and Vascular Anesthesia, 2011
- A combined a-EEG and MR spectroscopy study in term newborns with hypoxic–ischemic encephalopathyBrain & Development, 2010
- Neurodevelopment of Extremely Preterm Infants who had Necrotizing Enterocolitis with or without Late BacteremiaThe Journal of Pediatrics, 2010
- Normal cerebral, renal and abdominal regional oxygen saturations using near-infrared spectroscopy in preterm infantsJournal of Perinatology, 2010
- Neurological outcomes at 18 months of age after moderate hypothermia for perinatal hypoxic ischaemic encephalopathy: synthesis and meta-analysis of trial dataBMJ, 2010
- Pathophysiology of Anemia During the Neonatal Period, Including Anemia of PrematurityNeoReviews, 2008
- Research on the relationship between brain anoxia at different regional oxygen saturations and brain damage using near-infrared spectroscopyPhysiological Measurement, 2007
- Neurodevelopmental outcomes of neonates with medically and surgically treated necrotizing enterocolitisArchives of Disease in Childhood: Fetal & Neonatal, 2007
- Fluctuating Cerebral Blood-Flow Velocity in Respiratory-Distress SyndromeThe New England Journal of Medicine, 1983