NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas
Open Access
- 7 May 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cell Death & Disease
- Vol. 11 (5), 1-18
- https://doi.org/10.1038/s41419-020-2520-2
Abstract
In various malignant tumors, NF-kappa B interacting long noncoding RNA (NKILA) displays antitumor activity by inhibiting the NF-kappa B pathway. However, the role of NKILA in gliomas remains unclear. Surprisingly, this study showed that NKILA is significantly upregulated in gliomas, and the increased levels of NKILA were correlated with a decrease in patient survival time. NKILA increased the expression level of hypoxia-inducible factor-1 alpha, and the activity of the hypoxia pathway in gliomas. Furthermore, we demonstrated that NKILA enhances the Warburg effect and angiogenesis in gliomas both in vitro and in vivo. Therefore, NKILA is a potential therapeutic target in gliomas. In addition, we showed that a 20(S)-Rg3 monomer suppresses NKILA accumulation and reverses its stimulation of the Warburg effect and angiogenesis in gliomas, both in vitro and in vivo. Therefore, this study not only identified NKILA as a potential therapeutic target in gliomas, but also demonstrated a practical approach to treatment.This publication has 46 references indexed in Scilit:
- Roles of HIFs and VEGF in angiogenesis in the retina and brainJCI Insight, 2019
- LncRNA NKILA Inhibits Retinoblastoma by Downregulating lncRNA XISTCurrent Eye Research, 2019
- R406 elicits anti-Warburg effect via Syk-dependent and -independent mechanisms to trigger apoptosis in glioma stem cellsCell Death & Disease, 2019
- Long non-coding RNA GBCDRlnc1 induces chemoresistance of gallbladder cancer cells by activating autophagyMolecular Cancer, 2019
- 20(S)‐ginsenoside‐Rg3 reverses temozolomide resistance and restrains epithelial‐mesenchymal transition progression in glioblastomaCancer Science, 2018
- Long noncoding RNA MALAT1 suppresses breast cancer metastasisNature Genetics, 2018
- Cancer stem cell molecular reprogramming of the Warburg effect in glioblastomas: a new target gleaned from an old conceptCNS Oncology, 2016
- Long non-coding RNAs: new players in cell differentiation and developmentNature Reviews Genetics, 2013
- Long non-coding RNAs: A new frontier in the study of human diseasesCancer Letters, 2013
- EGFR-Induced and PKCε Monoubiquitylation-Dependent NF-κB Activation Upregulates PKM2 Expression and Promotes TumorigenesisMolecular Cell, 2012