Increased Expression of UMAMIT Amino Acid Transporters Results in Activation of Salicylic Acid Dependent Stress Response
Open Access
- 26 January 2021
- journal article
- research article
- Published by Frontiers Media SA in Frontiers in Plant Science
Abstract
In addition to their role in the biosynthesis of important molecules such as proteins and specialized metabolites, amino acids are known to function as signaling molecules through various pathways to report nitrogen status and trigger appropriate metabolic and cellular responses. Moreover, changes in amino acid levels through altered amino acid transporter activities trigger plant immune responses. Specifically, loss of function of major amino acid transporter, over-expression of cationic amino acid transporter, or over-expression of the positive regulators of membrane amino acid export all lead to dwarfed phenotypes and upregulated salicylic acid (SA)-induced stress marker genes. However, whether increasing amino acid exporter protein levels lead to similar stress phenotypes has not been investigated so far. Recently, a family of transporters, namely USUALLY MULTIPLE ACIDS MOVE IN AND OUT TRANSPORTERS (UMAMITs), were identified as amino acid exporters. The goal of this study was to investigate the effects of increased amino acid export on plant development, growth, and reproduction to further examine the link between amino acid transport and stress responses. The results presented here show strong evidence that an increased expression of UMAMIT transporters induces stress phenotypes and pathogen resistance, likely due to the establishment of a constitutive stress response via a SA-dependent pathway.Keywords
This publication has 63 references indexed in Scilit:
- Metabolic and Transcriptional Reprogramming in Developing Soybean (Glycine max) EmbryosMetabolites, 2013
- Ca2+ Conduction by an Amino Acid-Gated Ion Channel Related to Glutamate ReceptorsPlant Physiology, 2012
- Siliques Are Red1 from Arabidopsis Acts as a Bidirectional Amino Acid Transporter That Is Crucial for the Amino Acid Homeostasis of SiliquesPlant Physiology, 2012
- The Ubiquitin E3 Ligase LOSS OF GDU2 Is Required for GLUTAMINE DUMPER1-Induced Amino Acid Secretion in ArabidopsisPlant Physiology, 2012
- Stimulation of Nonselective Amino Acid Export by Glutamine Dumper ProteinsPlant Physiology, 2009
- Ustilago maydis Infection Strongly Alters Organic Nitrogen Allocation in Maize and Stimulates Productivity of Systemic Source LeavesPlant Physiology, 2009
- Downy Mildew Resistance in Arabidopsis by Mutation of HOMOSERINE KINASETHE PLANT CELL ONLINE, 2009
- Glutamate Receptor Subtypes Evidenced by Differences in Desensitization and Dependence on theGLR3.3andGLR3.4GenesPlant Physiology, 2007
- Calcium Entry Mediated by GLR3.3, an Arabidopsis Glutamate Receptor with a Broad Agonist ProfilePlant Physiology, 2006
- Arabidopsis LHT1 Is a High-Affinity Transporter for Cellular Amino Acid Uptake in Both Root Epidermis and Leaf MesophyllTHE PLANT CELL ONLINE, 2006