Cognitive function in patients with chronic lymphocytic leukemia: a cross-sectional study examining effects of disease and treatment
- 9 March 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 61 (7), 1627-1635
- https://doi.org/10.1080/10428194.2020.1728748
Abstract
Cancer-related cognitive impairment (CRCI) has not been objectively assessed in chronic lymphocytic leukemia (CLL). It is currently unclear how much of CRCI is attributable to disease, treatment, or both. We used CLL as a novel model to study the differential roles of disease and treatment in CRCI. One hundred and fifty CLL patients (100 treatment-naïve and 50 chemotherapy-treated) including 84 patients with higher-risk of CLL progression completed objective neuropsychological tests. Sociodemographic-adjusted linear regression models examined cognitive outcomes in relation to risk and treatment. Higher-risk patients recalled two fewer words on a memory task (β = −1.8, 95%CI –3.3,−0.3) and took 15 s longer on an executive function task (β = 15.4, 95%CI 3.1, 27.6) than lower-risk patients, independent of treatment. Treated patients reported greater cognitive difficulties than treatment-naive patients (β = −6.1, 95%CI –10.1, −2.2) but did not perform worse on objective measures. Higher-risk patients experienced impairments in executive function and memory suggesting that disease biology contributes to CRCI independent of treatment.This publication has 30 references indexed in Scilit:
- Impact of anxio-depressive symptoms and cognitive function on oral anticancer therapies adherenceSupportive Care in Cancer, 2019
- Longitudinal Trajectory and Characterization of Cancer-Related Cognitive Impairment in a Nationwide Cohort StudyJournal of Clinical Oncology, 2018
- Prevalence of Cognitive Impairment and Association With Survival Among Older Patients With Hematologic CancersJAMA Oncology, 2018
- Associations between inflammatory markers and cognitive function in breast cancer patients receiving chemotherapyJournal of Neuroimmunology, 2018
- Cognitive Complaints in Survivors of Breast Cancer After Chemotherapy Compared With Age-Matched Controls: An Analysis From a Nationwide, Multicenter, Prospective Longitudinal StudyJournal of Clinical Oncology, 2017
- Cognitive, behaviour, and academic functioning in adolescent and young adult survivors of childhood acute lymphoblastic leukaemia: a report from the Childhood Cancer Survivor StudyThe Lancet Psychiatry, 2016
- Impact of Cancer and Its Treatments on Cognitive Function: Advances in Research From the Paris International Cognition and Cancer Task Force Symposium and Update Since 2012Journal of Pain and Symptom Management, 2015
- Management of patients with chronic lymphocytic leukemia with a high risk of adverse outcome: the Mayo Clinic approachLeukemia & Lymphoma, 2011
- Cognitive and Psychological Factors Associated with Early Posttreatment Functional Outcomes in Breast Cancer SurvivorsJournal of Psychosocial Oncology, 2009
- Candidate mechanisms for chemotherapy-induced cognitive changesNature Reviews Cancer, 2007