New Search

Export article

Recent advances in lineage tracing for the kidney

Yoshiharu Muto,
Published: 1 July 2021

Abstract: Lineage tracing was originally developed by developmental biologists to identify all progeny of a single cell during morphogenesis. More recently this approach has been applied to other fields, including organ homeostasis and recovery from injury. Modern lineage tracing techniques typically rely on reporter gene expression induced by cell-specific DNA recombination. There have been important scientific advances in the last ten years that have impacted lineage tracing approaches, including intersectional genetics, optical clearing techniques and the use of sequencing-based genomic lineage tracing. The latter combines CRISPR-Cas9 based genetic scarring with single cell RNA-sequencing which in theory could allow comprehensive reconstruction of a lineage tree for an entire organism. In this review, we summarize recent advances in lineage tracing technologies and outline potential applications for kidney research.
Keywords: Cre Recombinase / lineage analysis / Crispr-Cas9

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

Share this article

Click here to see the statistics on "Kidney International" .
References (38)
    Back to Top Top