Distinct thalamocortical circuits underlie allodynia induced by tissue injury and by depression-like states
- 8 March 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 24 (4), 542-553
- https://doi.org/10.1038/s41593-021-00811-x
Abstract
In humans, tissue injury and depression can both cause pain hypersensitivity, but whether this involves distinct circuits remains unknown. Here, we identify two discrete glutamatergic neuronal circuits in male mice: a projection from the posterior thalamic nucleus (POGlu) to primary somatosensory cortex glutamatergic neurons (S1Glu) mediates allodynia from tissue injury, whereas a pathway from the parafascicular thalamic nucleus (PFGlu) to anterior cingulate cortex GABA-containing neurons to glutamatergic neurons (ACCGABA→Glu) mediates allodynia associated with a depression-like state. In vivo calcium imaging and multi-tetrode electrophysiological recordings reveal that POGlu and PFGlu populations undergo different adaptations in the two conditions. Artificial manipulation of each circuit affects allodynia resulting from either tissue injury or depression-like states, but not both. Our study demonstrates that the distinct thalamocortical circuits POGlu→S1Glu and PFGlu→ACCGABA→Glu subserve allodynia associated with tissue injury and depression-like states, respectively, thus providing insights into the circuit basis of pathological pain resulting from different etiologies.Keywords
Funding Information
- National Natural Science Foundation of China (81870877, 91849119)
- Funder:Fundamental Research Funds for the Central Universities
This publication has 59 references indexed in Scilit:
- What Is the Relationship between Pain and Emotion? Bridging Constructs and CommunitiesNeuron, 2020
- The Genetics of Neuropathic Pain from Model Organisms to Clinical ApplicationNeuron, 2019
- Spicy Immunity: Pain to GainImmunity, 2019
- Composite Pain Biomarker Signatures for Objective Assessment and Effective TreatmentNeuron, 2019
- Neuropathic painNature Reviews Disease Primers, 2017
- The pain of social disconnection: examining the shared neural underpinnings of physical and social painNature Reviews Neuroscience, 2012
- Deconstructing the Neuropathic Pain Phenotype to Reveal Neural MechanismsNeuron, 2012
- Nociceptors—Noxious Stimulus DetectorsNeuron, 2007
- Depression and Pain ComorbidityArchives of Internal Medicine, 2003
- Can we conquer pain?Nature Neuroscience, 2002