Exendin-4 does not modify growth or apoptosis of human colon cancer cells
- 20 March 2017
- journal article
- Published by Taylor & Francis Ltd in Endocrine Research
- Vol. 86, 1-10
- https://doi.org/10.1080/07435800.2017.1292525
Abstract
Glucagon-like peptide-1 (GLP-1) receptor agonists are a kind of very popular antidiabetes drugs. They promote cell proliferation and survival through activation of signaling pathways in human islet cells involving phosphate idylinositol 3 kinase (PI3K) and extracellular regulated kinases 1 and 2 (ERK1/2), which are frequently activated in human colon cancer cells. Then, it is possible that taking GLP-1 receptor (GLP-1R) agonists persistently would induce proliferation of β cells as well as colon cancer cells. So, clarifying the effects and mechanisms of GLP-1R agonists on colon cancer cells has important clinical implications.Keywords
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