Traditional Chinese Medicine Monomers: Novel Strategy for Endogenous Neural Stem Cells Activation After Stroke
Open Access
- 26 February 2021
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Cellular Neuroscience
Abstract
Stem cell therapy, which has become a potential regenerative medical treatment and a promising approach for treating brain injuries induced by different types of cerebrovascular disease, has various application methods. Activation of endogenous neural stem cells (NSCs) can enable infarcted neuron replacement and promote neural networks’ regeneration without the technical and ethical issues associated with the transplantation of exogenous stem cells. Thus, NSC activation can be a feasible strategy to treat central nervous system (CNS) injury. The potential molecular mechanisms of drug therapy for the activation of endogenous NSCs have gradually been revealed by researchers. Traditional Chinese medicine monomers (TCMs) are active components extracted from Chinese herbs, and some of them have demonstrated the potential to activate proliferation and neurogenesis of NSCs in CNS diseases. Ginsenoside Rg1, astragaloside IV (AST), icariin (ICA), salvianolic acid B (Sal B), resveratrol (RES), curcumin, artesunate (ART), and ginkgolide B (GB) have positive effects on NSCs via different signaling pathways and molecules, such as the Wingless/integrated/β-catenin (Wnt/β-catenin) signaling pathway, the sonic hedgehog (Shh) signaling pathway, brain-derived neurotrophic factor (BDNF), nuclear factor erythroid 2-related factor 2 (Nrf2), and heme oxygenase 1 (HO-1). This article may provide further motivation for researchers to take advantage of TCMs in studies on CNS injury and stem cell therapy.Keywords
This publication has 110 references indexed in Scilit:
- Resveratrol Inhibits the Proliferation of Neural Progenitor Cells and Hippocampal NeurogenesisOnline Journal of Public Health Informatics, 2012
- Direct Stimulation of Adult Neural Stem/Progenitor Cells In Vitro and Neurogenesis In Vivo by Salvianolic Acid BPLOS ONE, 2012
- Cognitive dysfunctions induced by a cholinergic blockade and Aβ25–35 peptide are attenuated by salvianolic acid BNeuropharmacology, 2011
- Review of the clinical pharmacokinetics of artesunate and its active metabolite dihydroartemisinin following intravenous, intramuscular, oral or rectal administrationMalaria Journal, 2011
- Chemical fingerprinting and quantitative analysis of a Panax notoginseng preparation using HPLC-UV and HPLC-MSChinese Medicine, 2011
- Increased subventricular zone-derived cortical neurogenesis after ischemic lesionExperimental Neurology, 2010
- REVIEW: Curcumin and Alzheimer's DiseaseCNS Neuroscience & Therapeutics, 2010
- Blood brain barrier permeability and therapeutic time window of Ginkgolide B in ischemia–reperfusion injuryEuropean Journal of Pharmaceutical Sciences, 2010
- Curcumin Stimulates Proliferation of Embryonic Neural Progenitor Cells and Neurogenesis in the Adult HippocampusOnline Journal of Public Health Informatics, 2008
- Immune or inflammatory response by the host brain suppresses neuronal differentiation of transplanted ES cell–derived neural precursor cellsJournal of Neuroscience Research, 2008