Early healing of peri‐implant mucosa in man
- 28 July 2016
- journal article
- Published by Wiley in Journal of Clinical Periodontology
- Vol. 43 (10), 816-824
- https://doi.org/10.1111/jcpe.12591
Abstract
To analyze (i) cellular and vascular densities in the connective tissue interface portion of the peri-implant mucosa and (ii) tissue interactions with the titanium surface during early stages of healing. Circumferential biopsies of peri-implant soft tissues were retrieved together with custom-made abutments at 27 implants in 21 patients after 2, 4, 6, 8 and 12 weeks of healing. Following fixation, the peri-implant soft tissue was separated from the abutments, divided into 4 units and embedded in paraffin. Sections were produced and prepared for immunohistochemical analysis. The abutments were examined by SEM. T and B cells occurred in clusters with a decreasing cell density from 4 to 8 weeks of healing in the connective tissue lateral of the abutment. Macrophages were evenly distributed in the connective tissue along the abutment/tissue interface, while PMN cells were confined to the tissue portion lateral to the junctional epithelium. Vascular structures showed a decrease in density from 2 weeks to 8 weeks of healing. SEM analyses of the abutments revealed an increased presence of tissue remnants attached to the surface with increasing healing time. A biofilm was consistently observed in a supra-mucosal position, apical of which a “clear zone” occurred that separated the tissue remnants and the biofilm. Onset and resolution of inflammation together with increasing tissue attachment to the implant characterize healing of peri-implant mucosa.Funding Information
- Dentsply Implants IH AB
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