A molecular quantitative trait locus map for osteoarthritis
Open Access
- 26 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Communications
- Vol. 12 (1), 1-11
- https://doi.org/10.1038/s41467-021-21593-7
Abstract
Osteoarthritis causes pain and functional disability for over 500 million people worldwide. To develop disease-stratifying tools and modifying therapies, we need a better understanding of the molecular basis of the disease in relevant tissue and cell types. Here, we study primary cartilage and synovium from 115 patients with osteoarthritis to construct a deep molecular signature map of the disease. By integrating genetics with transcriptomics and proteomics, we discover molecular trait loci in each tissue type and omics level, identify likely effector genes for osteoarthritis-associated genetic signals and highlight high-value targets for drug development and repurposing. These findings provide insights into disease aetiopathology, and offer translational opportunities in response to the global clinical challenge of osteoarthritis.Keywords
Funding Information
- Medical Research Council Centre for Integrated Research into Musculoskeletal Ageing grant
- Versus Arthritis; Tissue Engineering and Regenerative Therapies Centre
- Wellcome Trust (101123, 110140 and 110141)
- EC | Horizon 2020 Framework Programme (666869, THYRAGE)
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