Aneurysmal Fibrous Histiocytoma: A Large Soft Tissue Tumor with Metastases Treated with Palliative Radiation Therapy and Targeted Therapy
Open Access
- 1 January 2021
- journal article
- research article
- Published by S. Karger AG in Case Reports in Oncology
- Vol. 14 (1), 17-23
- https://doi.org/10.1159/000511073
Abstract
Aneurysmal fibrous histiocytoma (AFH) is a rare variant of cutaneous fibrous histiocytoma, with low malignant potential and infrequent metastatic progression. We present the case of a 19-year-old female with a large AFH of the neck metastatic to soft tissue and treated with radiation therapy and molecularly targeted therapy. To our knowledge, this is the first report describing either radiation therapy and palliation or the use of targeted therapy in this uncommon malignancy and can provide insight into future therapeutic strategies.This publication has 12 references indexed in Scilit:
- Gene fusion detection in formalin-fixed paraffin-embedded benign fibrous histiocytomas using fluorescence in situ hybridization and RNA sequencingLaboratory Investigation, 2015
- LAMTOR1-PRKCD and NUMA1-SFMBT1 fusion genes identified by RNA sequencing in aneurysmal benign fibrous histiocytoma with t(3;11)(p21;q13)Cancer Genetics, 2015
- Aneurysmal benign fibrous histiocytoma presenting as a giant acrochordon on thighIndian Dermatology Online Journal, 2015
- Fusions involving protein kinase C and membrane-associated proteins in benign fibrous histiocytomaThe International Journal of Biochemistry & Cell Biology, 2014
- CyberKnife radiotherapy for malignant fibrous histiocytoma of the chest wall: A case report and review of the literatureOncology Letters, 2014
- Metastasizing “Benign” Cutaneous Fibrous HistiocytomaThe American Journal of Surgical Pathology, 2013
- Deep “Benign” Fibrous Histiocytoma: Clinicopathologic Analysis of 69 Cases of a Rare Tumor Indicating Occasional Metastatic PotentialThe American Journal of Surgical Pathology, 2008
- Cutaneous aneurysmal fibrous histiocytoma with a t(12;19)(p12;q13) as the sole cytogenetic anomalyCancer Genetics and Cytogenetics, 2006
- The evolving classification of soft tissue tumours: an update based on the new WHO classificationHistopathology, 2005
- Metastasizing Fibrous Histiocytoma of the Skin: A Clinicopathologic and Immunohistochemical Analysis of Three CasesLaboratory Investigation, 2000