A Lycium barbarum extract inhibits β‐amyloid toxicity by activating the antioxidant system and mtUPR in a Caenorhabditis elegans model of Alzheimer's disease
- 19 January 2022
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 36 (2), e22156
- https://doi.org/10.1096/fj.202101116rr
Abstract
Lycium barbarum, a traditional Chinese medicine, has been shown to have antioxidant properties and has a protective effect in many diseases related to oxidative stress, such as neurodegenerative diseases, cardiovascular diseases, and cancer. Although the neuroprotective effects of L. barbarum extract (LBE) have been reported in several studies, the underlying molecular mechanisms are still unclear. In this study, the transgenic Caenorhabditis elegans strain CL2006 was used to investigate the function and molecular mechanism of an LBE in Alzheimer's disease (AD). LBE had high antioxidant potential and effectively delayed Aβ-induced paralysis in the CL2006 strain. LBE inhibited the production of excessive reactive oxygen species by inducing the SKN-1-mediated antioxidant system, thereby inhibiting the generation of Aβ and inhibiting mitochondrial damage. Importantly, LBE reduced Aβ levels by inducing FSHR-1-mediated activation of the mtUPR. Therefore, our study not only reveals a new mechanism of LBE in the treatment of AD but also identifies a novel strategy for the treatment of AD by enhancing the mtUPR.Keywords
Funding Information
- Chinese Academy of Sciences (XDB39000000)
- Chinese Academy of Sciences (KFJ‐STS‐QYZD‐181)
- National Natural Science Foundation of China (91849203)
This publication has 35 references indexed in Scilit:
- The effects of Gouqi extracts on Morris maze learning in the APP/PS1 double transgenic mouse model of Alzheimer’s diseaseExperimental and Therapeutic Medicine, 2013
- Understanding the molecular basis of Alzheimer’s disease using a Caenorhabditis elegans model systemBrain Structure and Function, 2009
- Current and future therapy in Alzheimer’s diseaseFundamental & Clinical Pharmacology, 2008
- Effects of the novel anthelmintic emodepside on the locomotion, egg-laying behaviour and development of Caenorhabditis elegansInternational Journal for Parasitology, 2007
- NEURODEGENERATIVE DISEASES: New Concepts of Pathogenesis and Their Therapeutic ImplicationsAnnual review of pathology, 2006
- Compartment-specific perturbation of protein handling activates genes encoding mitochondrial chaperonesJournal of Cell Science, 2004
- ABAD Directly Links Aß to Mitochondrial Toxicity in Alzheimer's DiseaseScience, 2004
- Systematic functional analysis of the Caenorhabditis elegans genome using RNAiNature, 2003
- IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNANature, 2002
- ALZHEIMER'S DISEASE: PAIRED HELICAL FILAMENTS AND CYTOMEMBRANESNeuropathology and Applied Neurobiology, 1987