Sealing holes in cellular membranes
Open Access
- 1 March 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in The EMBO Journal
- Vol. 40 (7), e106922
- https://doi.org/10.15252/embj.2020106922
Abstract
The compartmentalization of eukaryotic cells, which is essential for their viability and functions, is ensured by single or double bilayer membranes that separate the cell from the exterior and form boundaries between the cell’s organelles and the cytosol. Nascent nuclear envelopes and autophagosomes, which both are enveloped by double membranes, need to be sealed during the late stage of their biogenesis. On the other hand, the integrity of cellular membranes such as the plasma membrane, lysosomes and the nuclear envelope can be compromised by pathogens, chemicals, radiation, inflammatory responses and mechanical stress. There are cellular programmes that restore membrane integrity after injury. Here, we review cellular mechanisms that have evolved to maintain membrane integrity during organelle biogenesis and after injury, including membrane scission mediated by the endosomal sorting complex required for transport (ESCRT), vesicle patching and endocytosis.Keywords
Funding Information
- Norges Forskningsråd (262652, 302994)
- Helse Sør-Øst RHF (2016087, 2018043)
- Kreftforeningen (182698)
- H2020 European Research Council (788954)
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