Ventral arkypallidal neurons inhibit accumbal firing to promote reward consumption
- 28 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 24 (3), 379-390
- https://doi.org/10.1038/s41593-020-00772-7
Abstract
The nucleus accumbens shell (NAcSh) and the ventral pallidum (VP) are critical for reward processing, although the question of how coordinated activity within these nuclei orchestrates reward valuation and consumption remains unclear. Inhibition of NAcSh firing is necessary for reward consumption, but the source of this inhibition remains unknown. Here, we report that a subpopulation of VP neurons, the ventral arkypallidal (vArky) neurons, project back to the NAcSh, where they inhibit NAcSh neurons in vivo in mice. Consistent with this pathway driving reward consumption via inhibition of the NAcSh, calcium activity of vArky neurons scaled with reward palatability (which was dissociable from reward seeking) and predicted the subsequent drinking behavior during a free-access paradigm. Activation of the VP-NAcSh pathway increased ongoing reward consumption while amplifying hedonic reactions to reward. These results establish a pivotal role for vArky neurons in the promotion of reward consumption through modulation of NAcSh firing in a value-dependent manner. Inhibition of nucleus accumbens neurons is crucial for reward consumption. Vachez, Tooley et al. characterize arkypallidal neurons in the ventral pallidum that inhibit accumbal neurons to sustain reward consumption in a value-dependent manner.Funding Information
- Brain and Behavior Research Foundation (27197)
- Rita Allen Foundation (Scholar award in Pain)
- U.S. Department of Health & Human Services | NIH | National Institute on Drug Abuse (R21-DA047127, R01-DA049924)
This publication has 61 references indexed in Scilit:
- Ventral tegmental area GABA projections pause accumbal cholinergic interneurons to enhance associative learningNature, 2012
- Fiji: an open-source platform for biological-image analysisNature Methods, 2012
- Dichotomous Organization of the External Globus PallidusNeuron, 2012
- Activation of VTA GABA Neurons Disrupts Reward ConsumptionNeuron, 2012
- Recombinase-Driver Rat Lines: Tools, Techniques, and Optogenetic Application to Dopamine-Mediated ReinforcementNeuron, 2011
- Slow phasic and tonic activity of ventral pallidal neurons during cocaine self‐administrationSynapse, 2011
- Optogenetic Interrogation of Dopaminergic Modulation of the Multiple Phases of Reward-Seeking BehaviorJournal of Neuroscience, 2011
- Roles of Nucleus Accumbens Core and Shell in Incentive-Cue Responding and Behavioral InhibitionJournal of Neuroscience, 2011
- Hedonic and nucleus accumbens neural responses to a natural reward are regulated by aversive conditioningLearning & Memory, 2010
- A Pause in Nucleus Accumbens Neuron Firing Is Required to Initiate and Maintain FeedingJournal of Neuroscience, 2010