Lifelong reductions of PKMζ in ventral hippocampus of nonhuman primates exposed to early-life adversity due to unpredictable maternal care
Open Access
- 16 August 2021
- journal article
- research article
- Published by Cold Spring Harbor Laboratory in Learning & Memory
- Vol. 28 (9), 341-347
- https://doi.org/10.1101/lm.053468.121
Abstract
Protein kinase Mζ (PKMζ) maintains long-term potentiation (LTP) and long-term memory through persistent increases in kinase expression. Early-life adversity is a precursor to adult mood and anxiety disorders, in part, through persistent disruption of emotional memory throughout life. Here we subjected 10- to 16-wk-old male bonnet macaques to adversity by a maternal variable-foraging demand paradigm. We then examined PKMζ expression in their ventral hippocampi as 7- to 12-yr-old adults. Quantitative immunohistochemistry reveals decreased PKMζ in dentate gyrus, CA1, and subiculum of subjects who had experienced early-life adversity due to the unpredictability of maternal care. Adult animals with persistent decrements of PKMζ in ventral hippocampus express timid rather than confrontational responses to a human intruder. Persistent down-regulation of PKMζ in the ventral hippocampus might reduce the capacity for emotional memory maintenance and contribute to the long-lasting emotional effects of early-life adversity.Keywords
This publication has 48 references indexed in Scilit:
- PKM and the maintenance of memoryF1000 Biology Reports, 2013
- Synaptic Distributions of GluA2 and PKMζ in the Monkey Dentate Gyrus and Their Relationships with Aging and MemoryJournal of Neuroscience, 2012
- The Effects of Mindfulness-Based Cognitive Therapy on Affective Memory Recall Dynamics in Depression: A Mechanistic Model of RuminationFrontiers in Human Neuroscience, 2012
- Correlations between Hippocampal Neurogenesis and Metabolic Indices in Adult Nonhuman PrimatesNeural Plasticity, 2011
- Brain Plasticity and Disease: A Matter of InhibitionNeural Plasticity, 2011
- Early-life stress, corpus callosum development, hippocampal volumetrics, and anxious behavior in male nonhuman primatesPsychiatry Research: Neuroimaging, 2011
- Are the Dorsal and Ventral Hippocampus Functionally Distinct Structures?Neuron, 2010
- Cellular networks underlying human spatial navigationNature, 2003
- Effects of lesions to amygdala, ventral subiculum, medial prefrontal cortex, and nucleus accumbens on the reaction to novelty: Implications for limbic--striatal interactions.Behavioral Neuroscience, 1996
- Eta-Squared and Partial Eta-Squared in Fixed Factor Anova DesignsEducational and Psychological Measurement, 1973