Association of proportion of the HDL-cholesterol subclasses HDL-2b and HDL-3 and macrovascular events among patients undergoing hemodialysis
Open Access
- 21 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Scientific Reports
- Vol. 11 (1), 1-8
- https://doi.org/10.1038/s41598-021-81636-3
Abstract
Altered high-density lipoprotein cholesterol (HDL-C) subclass distribution in hemodialysis (HD) patients is well documented. Aim of this study is to investigate the relationship between HDL-C subclass distribution and macrovascular events in patients undergoing HD. A total of 164 prevalent HD patients and 71 healthy individuals in one hospital-facilitated clinic were enrolled from May 2019 to July 2019 and individual HD patients was follow-up for one year. Macrovascular events (cerebral stroke, coronary heart disease) were recorded in the study period. The HDL-2b, HDL-3 proportions and biochemical parameters were measured. Pearson correlation test and logistic regression analysis were used to examine correlation and odds ratio (OR). 144 HD patients completed one-year follow-up. Cohort with macrovascular events revealed significantly lower HDL-2b and higher HDL-3 subclass proportions compared to those without events. By multivariable adjustment, HDL-3 subclass proportion revealed significantly increase risk for these events (OR 1.17, 95% CI 1.02–1.41, P = 0.044). HDL-2b subclass was significantly higher and HDL-3 subclass was significantly lower in the HD cohort under the hs-CRP level of < 3 mg/L compared to higher hs-CRP level. In conclusion, HDL-2b and HDL-3 subclasses distributions were associated with macrovascular events in HD patients. Proinflammatory status influences the distribution of HDL-2b and HDL-3 subclasses in HD patients.Funding Information
- Kaohsiung Chang Gung Memorial Hospital (CMRPG8J0031, CMRPG8J0031)
This publication has 42 references indexed in Scilit:
- Increasing high-sensitive C-reactive protein level predicts peritonitis risk in chronic peritoneal dialysis patientsBMC Nephrology, 2013
- C-reactive protein/oxidised low-density lipoprotein/β2-glycoprotein I complex promotes atherosclerosis in diabetic BALB/c mice via p38mitogen-activated protein kinase signal pathwayLipids in Health and Disease, 2013
- Uremia Alters HDL Composition and FunctionJournal of the American Society of Nephrology, 2011
- HDL metabolism and activity in chronic kidney diseaseNature Reviews Nephrology, 2010
- Serum Oxidized LDL Is Inversely Associated with HDL2-Cholesterol Subclass in Renal Failure Patients on HemodialysisNephron Clinical Practice, 2010
- Cerebrovascular Disease Incidence, Characteristics, and Outcomes in Patients Initiating Dialysis: The Choices for Healthy Outcomes in Caring for ESRD (CHOICE) StudyAmerican Journal of Kidney Diseases, 2009
- HDL-inflammatory index correlates with poor outcome in hemodialysis patientsKidney International, 2007
- Traditional and emerging cardiovascular and renal risk factors: An epidemiologic perspectiveKidney International, 2006
- Kidney Disease as a Risk Factor for Development of Cardiovascular DiseaseHypertension, 2003
- Down-regulation of hepatic lecithin:cholesterol acyltransferase gene expression in chronic renal failureKidney International, 2001