Discovery of Soluble Epoxide Hydrolase Inhibitors from Chemical Synthesis and Natural Products
- 28 December 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 64 (1), 184-215
- https://doi.org/10.1021/acs.jmedchem.0c01507
Abstract
Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively maintain endogenous epoxyeicosatrienoic acids (EETs) levels and reduce dihydroxyeicosatrienoic acids (DHETs) levels, resulting in therapeutic potentials for cardiovascular, central nervous system, and metabolic diseases. Therefore, since the beginning of this century, the development of sEH inhibitors is a hot research topic. A variety of potent sEH inhibitors have been developed by chemical synthesis or isolated from natural sources. In this review, we mainly summarized the interconnected aspects of sEH with cardiovascular, central nervous system, and metabolic diseases and then focus on representative inhibitors, which would provide some useful guidance for the future development of potential sEH inhibitors.Keywords
Funding Information
- National Institute of Environmental Health Sciences (P42 ES0469, R35 ES030443)
- Ministry of Science and Technology of the People's Republic of China (2018YFC1705900)
- Natural Science Foundation of Liaoning Province (2020-MS-256)
- National Natural Science Foundation of China (81930112)
- Distinguished Professor of Liaoning Province
- Liaoning Provincial Key Research and Development Program (2019JH2/10300022)
- Liaoning Revitalization Talents Program
- Dalian Young Star of Science and Technology
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