Risk factors for astigmatic components and internal compensation: the Nanjing Eye Study
Open Access
- 1 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Eye
- Vol. 35 (2), 499-507
- https://doi.org/10.1038/s41433-020-0881-5
Abstract
Purpose To determine the risk factors for total astigmatism (TA), anterior corneal astigmatism (ACA), and internal compensation in Chinese preschool children. Methods In the population-based Nanjing Eye Study, children were measured for noncycloplegic refractive error and for biometric parameters. Data from questionnaires and measures from right eyes were analyzed for determining risk factors for TA, ACA, and internal compensation from multivariate logistic regression models. Results Of 1327 children (66.8 +/- 3.4 months, 53.2% male), older age of the child (OR = 0.95 for per month increase; P = 0.03), older paternal age at child birth (OR = 1.04 for per year increase; P = 0.03), paternal astigmatism (OR = 1.89; P = 0.003), maternal astigmatism (OR = 1.73, P = 0.008), and second-hand smoke exposure during pregnancy (OR = 1.64; P = 0.03) were associated with higher risk of TA, while partial breastfeeding (OR = 0.49, P = 0.006) or formula feeding (OR = 0.46, P = 0.003) were associated with lower risk of TA. Larger ratio of axial length to corneal radius (OR = 16.16 for per unit increase; P = 0.001), maternal working during pregnancy (OR = 1.27; P = 0.04), and cesarean delivery (OR = 1.68, P = 0.04) were associated with higher risk of ACA, while formula feeding was associated with lower risk of ACA (OR = 0.57, P = 0.01). Paternal astigmatism (OR = 0.50, P = 0.01) and assisted reproduction (OR = 0.56, P = 0.03) were associated with lower risk of horizontal or vertical internal compensation. More outdoor activity time (OR = 1.15 for per hour increase, P = 0.01) was associated with higher risk of oblique internal compensation while more nighttime sleep on weekends (OR = 0.83 for per hour increase, P = 0.01) was associated with lower risk of oblique internal compensation. Conclusions Our study confirmed some previously reported risk factors and identified some novel risk factors for astigmatism including formula feeding for lower risk of both ACA and TA, and older paternal age at child birth for higher risk of TA.Keywords
This publication has 51 references indexed in Scilit:
- Genome-Wide Meta-Analysis of Five Asian Cohorts Identifies PDGFRA as a Susceptibility Locus for Corneal AstigmatismPLoS Genetics, 2011
- Risk Factors for Astigmatism in Preschool Children: The Multi-Ethnic Pediatric Eye Disease and Baltimore Pediatric Eye Disease StudiesOphthalmology, 2011
- Shorter Axial Length and Increased Astigmatic Refractive Error are Associated With Socio-Economic Deprivation in an Adult UK CohortOphthalmic Epidemiology, 2010
- Breastfeeding and association with refractive error in young Singapore Chinese childrenEye, 2009
- Dominant Genetic Effects on Corneal Astigmatism: The Genes in Myopia (GEM) Twin StudyPublished by Association for Research in Vision and Ophthalmology (ARVO) ,2008
- Heritability of Corneal Curvature and AstigmatismCornea, 2007
- Ophthalmological findings in children born after intracytoplasmic sperm injectionActa Ophthalmologica Scandinavica, 2005
- Astigmatism and its Determinants in the Tehran Population: The Tehran Eye StudyOphthalmic Epidemiology, 2005
- Genetic and Environmental Effects on Oculometric TraitsOptometry and Vision Science, 1989
- REFRACTION PEDIGREESOptometry and Vision Science, 1965