The Effect of Used Immunostimulating Drugs with FMD Vaccine on Immunoglobulins in Sheep
- 12 March 2020
- journal article
- Published by Van Veterinary Journal in Van Veterinary Journal
- Vol. 31 (1), 15-21
- https://doi.org/10.36483/vanvetj.547457
Abstract
Tr en Koyunlarda şap aşısı ile birlikte kullanılan immunstimülan ilaçların immunglobülinler üzerine etkisi araştırıldı. Bu amaçla 40 adet sağlıklı koyun 4 gruba ayrıldı. Çalışma öncesinde tüm hayvanlardan 0. gün kan ve serum örnekleri alındı. Hematolojik parameterler hemen ölçüldü, biyokimyasal parametrelerden IgA, IgG, IgM, IgE ve Zn değerleri ölçülmek üzere serumlar saklandı. I. gruba sadece şap aşısı uygulandı, II. gruba şap aşısı ile birlikte Levamizol, III. gruba şap aşısı ile birlikte Çinko ve son grup olan IV. gruba da şap aşısı ile birlikte AD3E vitamini uygulandı. 21gün sonra tüm gruplardan kan ve serum örnekleri tekrar alındı ve 0. gün değerlerine göre hem hematolojik hem de IgA, IgG, IgM, IgE ve Zn değerleri kıyaslandı. Hematolojik parametrelerin PLT ve NEU hariç gruplar arasında herhangi bir istatistiksel fark belirlenmedi. 0. ve 21. günlere göre kıyaslamada II. ve III. gruplarda PLT düzeylerinde önemli artış (p3E was applied with FMD vaccine. After 21 days, blood and serum samples from all groups were taken again and hematologic and IgA, IgG, IgM, IgE and Zn values were compared according to the values of day 0. No statistical difference was found between the groups except for PLT in hematological parameters (p> 0, 05) when compared to pre-vaccination and post-vaccination. In groups II and III there was a significant increase in PLT levels. Biochemical analysis showed IgA, IgG, IgM and IgE levels to be higher in IgG (p <0,05) and IgE (p <0,001)in groups II and III when levels compared to before vaccination. There were statistically significant increases in IgM (p <0.05) in group IV.Keywords
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