A Concise Approach to N-Substituted Rhodanines through a Base-Assisted One-Pot Coupling and Cyclization Process
Open Access
- 4 March 2020
- Vol. 25 (5), 1138
- https://doi.org/10.3390/molecules25051138
Abstract
An efficient approach to obtain functionalized rhodanines was developed through a base-assisted one-pot coupling and continuous cyclization of a primary amine, carbon disulfide, and methyl (2-chloroacetyl)carbamate. This conversion tolerates a broad range of functional groups and can be used to scale the preparation of N-substituted rhodanines in excellent yields.Funding Information
- National Natural Science Foundation of China (81673297 and 81903422)
- Science and Technology Commission of Shanghai Municipality (17JC1400200)
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