Relationship between Heart Disease and Liver Disease: A Two-Way Street
Top Cited Papers
Open Access
- 27 February 2020
- Vol. 9 (3), 567
- https://doi.org/10.3390/cells9030567
Abstract
In clinical practice, combined heart and liver dysfunctions coexist in the setting of the main heart and liver diseases because of complex cardiohepatic interactions. It is becoming increasingly crucial to identify these interactions between heart and liver in order to ensure an effective management of patients with heart or liver disease to provide an improvement in overall prognosis and therapy. In this review, we aim to summarize the cross-talk between heart and liver in the setting of the main pathologic conditions affecting these organs. Accordingly, we present the clinical manifestation, biochemical profiles, and histological findings of cardiogenic ischemic hepatitis and congestive hepatopathy due to acute and chronic heart failure, respectively. In addition, we discuss the main features of cardiac dysfunction in the setting of liver cirrhosis, nonalcoholic fatty liver disease, and those following liver transplantation.Keywords
This publication has 129 references indexed in Scilit:
- Additive relationship between serum fibroblast growth factor 21 level and coronary artery diseaseCardiovascular Diabetology, 2013
- A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13Cell, 2012
- Liver Abnormalities in Cardiac Diseases and Heart FailureInternational Journal of Angiology, 2011
- Presence of Coronary Plaques in Patients with Nonalcoholic Fatty Liver DiseaseRadiology, 2010
- TNF-α inhibition attenuates adverse myocardial remodeling in a rat model of volume overloadAmerican Journal of Physiology-Heart and Circulatory Physiology, 2009
- Endocannabinoids acting at CB1receptors mediate the cardiac contractile dysfunction in vivo in cirrhotic ratsAmerican Journal of Physiology-Heart and Circulatory Physiology, 2007
- Hepatic changes in the failing Fontan circulationHeart, 2007
- Cirrhotic cardiomyopathyOrphanet Journal of Rare Diseases, 2007
- Insulin resistance and atherosclerosisJCI Insight, 2006
- Impaired Left Ventricular Function in Alcoholic Cirrhosis With AscitesCirculation, 1974