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In vivo human whole-brain Connectom diffusion MRI dataset at 760 µm isotropic resolution

, Zijing Dong, , Congyu Liao, Qiuyun Fan, W. Scott Hoge, Boris Keil, , Lawrence L. Wald,
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Published: 29 April 2021
Scientific Data , Volume 8, pp 1-12; doi:10.1038/s41597-021-00904-z

Abstract: We present a whole-brain in vivo diffusion MRI (dMRI) dataset acquired at 760 μm isotropic resolution and sampled at 1260 q-space points across 9 two-hour sessions on a single healthy participant. The creation of this benchmark dataset is possible through the synergistic use of advanced acquisition hardware and software including the high-gradient-strength Connectom scanner, a custom-built 64-channel phased-array coil, a personalized motion-robust head stabilizer, a recently developed SNR-efficient dMRI acquisition method, and parallel imaging reconstruction with advanced ghost reduction algorithm. With its unprecedented resolution, SNR and image quality, we envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance the understanding of human brain structures and connectivity. This comprehensive dataset can also be used as a test bed for new modeling, sub-sampling strategies, denoising and processing algorithms, potentially providing a common testing platform for further development of in vivo high resolution dMRI techniques. Whole brain anatomical T1-weighted and T2-weighted images at submillimeter scale along with field maps are also made available.
Keywords: diffusion / human brain / resolution / isotropic / SNR / structures / dMRI / vivo

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