PRMT5 Inhibition Modulates E2F1 Methylation and Gene-Regulatory Networks Leading to Therapeutic Efficacy in JAK2V617F-Mutant MPN

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Abstract
A small-molecule inhibitor of the protein arginine methyltransferase PRMT5 was effective in mouse models of the myeloproliferative neoplasms polycythemia vera and myelofibrosis and synergized with JAK1/2 inhibition.
Funding Information
  • German Research Foundation (PA 2541/1-1)
  • NIH (P30 CA008748)
  • National Cancer Institute (R35 CA197594-01A1)
  • National Cancer Institute (P01 CA108671)
  • Damon Runyon Cancer Research Foundation (DRG 22-17)
  • National Cancer Institute (K99 CA248460)
  • German Research Foundation (PA 2541/1-1)