Centrosome-phagy: implications for human diseases
Open Access
- 4 March 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell & Bioscience
- Vol. 11 (1), 1-13
- https://doi.org/10.1186/s13578-021-00557-w
Abstract
Autophagy is a prominent mechanism to preserve homeostasis and the response to intracellular or extracellular stress. Autophagic degradation can be selectively targeted to dysfunctional subcellular compartments. Centrosome homeostasis is pivotal for healthy proliferating cells, but centrosome aberration is a hallmark of diverse human disorders. Recently, a process called centrosome-phagy has been identified. The process involves a panel of centrosomal proteins and centrosome-related pathways that mediate the specific degradation of centrosomal components via the autophagic machinery. Although autophagy normally mediates centrosome homeostasis, autophagy defects facilitate ageing and multiple human diseases, such as ciliopathies and cancer, which benefit from centrosome aberration. Here, we discuss the molecular systems that trigger centrosome-phagy and its role in human disorders.Funding Information
- National Natural Science Foundation of China (81471781, 81903166)
- National Key Scientific Instrument and Equipment Development Projects of China (2012YQ160203)
- Graduate Research and Innovation Projects of Jiangsu Province (WJ2019Q053)
- Natural Science Foundation of Hubei (2018CKB916)
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