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Biomarkers for neurodegenerative diseases

Published: 3 June 2021
Nature Medicine , Volume 27, pp 954-963; doi:10.1038/s41591-021-01382-x

Abstract: Biomarkers for neurodegenerative diseases are needed to improve the diagnostic workup in the clinic but also to facilitate the development and monitoring of effective disease-modifying therapies. Positron emission tomography methods detecting amyloid-β and tau pathology in Alzheimer’s disease have been increasingly used to improve the design of clinical trials and observational studies. In recent years, easily accessible and cost-effective blood-based biomarkers detecting the same Alzheimer’s disease pathologies have been developed, which might revolutionize the diagnostic workup of Alzheimer’s disease globally. Relevant biomarkers for α-synuclein pathology in Parkinson’s disease are also emerging, as well as blood-based markers of general neurodegeneration and glial activation. This review presents an overview of the latest advances in the field of biomarkers for neurodegenerative diseases. Future directions are discussed regarding implementation of novel biomarkers in clinical practice and trials. As the development of biomarkers for neurodegenerative diseases advances, new opportunities arise for their implementation in clinical practice and trials.
Keywords: Diagnostic markers / Neurodegenerative diseases / Prognostic markers / Biomedicine / general / Cancer Research / Metabolic Diseases / Infectious Diseases / Molecular Medicine / Neurosciences

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