This study aims to determine the effect of interest in learning on the ability to read English Vocational High School students in Depok. The method used was a survey method with a total sample of 40 students taken by random sampling technique from three private vocational schools in Depok. Learning interest data collection uses a questionnaire in the form of a rating scale, while the ability to read English students is presented in the form of a written test with multiple choice questions. Both test instruments are first validated. Data analysis uses two-way analysis of variance (ANAVA) by first testing the normality and homogeneity tests. The results of the study there is a significant influence of interest in learning on the ability to read English students proven by the value of ρ value = 0.024