Motile mosquito stage malaria parasites: ready for their close‐up

Abstract

Many stages of the complex Plasmodium parasite life cycle, the eukaryotic pathogen that causes malaria, are extracellular and motile. This motility is essential for life cycle progression, and two studies in this issue of EMBO Molecular Medicine (Hopp et al, 2021; Ripp et al, 2021) examine the motility of two of these life cycle stages. These are the ookinete, which develops in the midgut of an infected mosquito vector, and the sporozoite, which is injected into the skin of an unsuspecting host by an infected mosquito, initiating the parasite life cycle in the human. Therapeutic targeting of the ookinete and sporozoite (Duffy & Patrick Gorres, 2020), which are profound bottlenecks in the life cycle, has recently received a great deal of attention in our battle to prevent the 400,000 deaths from malaria that occur every year (WHO, 2020).