Correlation between Serological Biomarkers and Disease Activity in Patients with Inflammatory Bowel Disease
Open Access
- 26 December 2019
- journal article
- research article
- Published by Hindawi Limited in BioMed Research International
- Vol. 2019, 1-7
- https://doi.org/10.1155/2019/6517549
Abstract
Background. Current biomarkers have been routinely used noninvasive methods for assessing disease activity of inflammatory bowel disease (IBD), but none of them are specific. This study was aimed to determine the performance of the serological biomarkers for detecting disease activity in patients with IBD. Methods. A prospective study that included 73 ulcerative disease (UC) subjects, 141 Crohn’s disease (CD) subjects, and 30 of them complicated with C. difficile infection (CDI) were diagnosed at a single-institution IBD center. Disease activity was assessed using by Truelove and Witts criteria for UC and Harvey Bradshaw Simple Index for CD. Serological inflammatory biomarkers were compared in different severity groups. Receiver operator curve analyses assessed the performance of each biomarker in discriminating disease states. Results. For UC patients, elevated monocyte counts, C-reactive protein (CRP), and decreased lymphocyte counts and lymphocyte/monocyte ratio (LMR) significantly differed between subjects with active and inactive UC. LMR of 3.1 was 76% sensitive and had a specificity of 67% for active UC. For CD patients, higher values of neutrophils, monocytes, neutrophil/lymphocyte ratio, CRP, fibrinogen, and lower values of LMR and hemoglobin were significantly different between subjects with active and inactive CD. None of the biomarkers included had a good correlation with disease activity (area under the ROC Curve < 0.70). Conclusions. A low LMR represents an inexpensive, readily available test with a promising value to identify disease activity in UC patients, whereas none of the inflammatory biomarkers showed a discriminative value in disease activity of CD.Funding Information
- National Natural Science Foundation of China (81700456, 2018KY104, LQ19H030013)
This publication has 32 references indexed in Scilit:
- Are We Ready to Include Prognostic Factors in Inflammatory Bowel Disease Trials?Current Pharmaceutical Design, 2019
- Relationship Between the Reciprocal Change in Inflammation-Related Biomarkers (Fibrinogen-to-Albumin and hsCRP-to-Albumin Ratios) and the Presence and Severity of Coronary Slow FlowClinical and Applied Thrombosis/hemostasis, 2019
- Dynamics of Colon Monocyte and Macrophage Activation During ColitisFrontiers in Immunology, 2018
- IBD immunopathogenesis: A comprehensive review of inflammatory moleculesAutoimmunity Reviews, 2017
- Fecal calprotectin in inflammatory bowel diseases: update and perspectivescclm, 2017
- Correlations of C-reactive Protein Levels and Erythrocyte Sedimentation Rates with Endoscopic Activity Indices in Patients with Ulcerative ColitisDigestive Diseases and Sciences, 2013
- Elevated markers of thrombin generation and fibrinolysis in patients with active and quiescent ulcerative colitis.2009
- C-reactive protein: a predictive factor and marker of inflammation in inflammatory bowel disease. Results from a prospective population-based studyGut, 2008
- Role of Serology and Routine Laboratory Tests in Childhood Inflammatory Bowel DiseaseInflammatory Bowel Diseases, 2002
- Intestinal lymphocyte subpopulations in inflammatory bowel disease: an analysis by immunohistological and cell isolation techniques.Gut, 1984