Metabolically Healthy Obesity (MHO)-New Research Directions for Personalised Medicine in Cardiovascular Prevention
Open Access
- 17 February 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Current Hypertension Reports
- Vol. 22 (2), 1-5
- https://doi.org/10.1007/s11906-020-1027-7
Abstract
Purpose of Review To discuss new findings on the heterogeneity of obesity and associated risks. Recent Findings Obesity is a public health problem of immense importance on a global scale. However, epidemiological findings and clinical studies have revealed that obesity is a heterogeneous phenotype and that not all obese subjects run the same risk for complications. Current research has tried to describe so-called metabolically healthy obesity (MHO), defined by lack of risk factors included in the metabolic syndrome. These subjects will not escape long-term complications, but mortality risk is not increased. However, a new definition of MHO has recently been proposed, based on the lack of hospitalisation for somatic disease for decades in middle life. MHO subjects defined in this way are characterised by being "fat and fit" and also run a lower risk of long-term complications. If MHO could be better understood, this could contribute to a more diverse clinical approach to obesity based on personalised medicine.Funding Information
- Lund University
This publication has 35 references indexed in Scilit:
- Liraglutide and Cardiovascular Outcomes in Type 2 DiabetesThe New England Journal of Medicine, 2016
- Metabolically healthy obesity and cardiovascular events: A systematic review and meta-analysisEuropean Journal of Preventive Cardiology, 2016
- The Effects of Bariatric Surgery on Cardiac Structure and Function: a Systematic Review of Cardiac Imaging OutcomesObesity Surgery, 2015
- NAFLD: A multisystem diseaseJournal of Hepatology, 2015
- Country of birth modifies the associations of body mass and hemoglobin A1c with office blood pressure in Middle Eastern immigrants and native SwedesJournal of Hypertension, 2014
- Are Metabolically Healthy Overweight and Obesity Benign Conditions?Annals of Internal Medicine, 2013
- Metabolically Healthy Obesity and Risk of MortalityDiabetes Care, 2013
- Effect of Sibutramine on Cardiovascular Outcomes in Overweight and Obese SubjectsThe New England Journal of Medicine, 2010
- Characteristics of Type 1 diabetes of over 50 years duration (the Golden Years Cohort)Diabetic Medicine, 2003
- The enigma of increased non‐cancer mortality after weight loss in healthy men who are overweight or obeseJournal of Internal Medicine, 2002