SYNTHESIS AND BIOLOGICAL ACTIVITY OF 3d-METAL COMPLEXES WITH BIS(PHOSPHONOMETHYL)AMINOSUNRIC ACID
- 28 October 2022
- journal article
- Published by V.I. Vernadsky Institute of General and Inorganic Chemistry in Ukrainian Chemistry Journal
- Vol. 88 (9), 3-24
- https://doi.org/10.33609/2708-129x.88.09.2022.3-24
Abstract
New complexes of 3d-metals (Co2+, Ni2+, Zn2+) with bis(phosphonomethyl)aminosuccinic acid (H6BPMAS) have been synthesized. The complexes were studied in aqueous solutions at ratios M2+:H6BPMAS = 1:1 in a wide pH range (1÷10). Regardless of the nature of the metal, the formation of complexes of the general composition [M(HnBPMAS)(OH)m] (n= 4÷0, m=1÷0) is shown. The stability constants of the formed differently protonated complexes are calculated and diagrams of their distribution are plotted. It is shown that the process of complexation takes place most completely in the region of pH>4. For all bis(phosphonomethyl)aminosuccinates of 3d metals, the dominance of the complex with one form of the ligand occurs in approximately the same pH ranges. A close order of change in the values of lgKst. complexes testifies to the same type of structure of their internal coordination sphere. Solid complexes of the composition Na4[MBPMAS]⋅4H2O were synthesized. Their composition, structure, and thermal characteristics were determined by the set of methods such as diffuse reflectance spectroscopy, IR spectroscopy, DTA and non-quantitative mass spectrometry. It is proved that the complexes have the structure of a distorted octahedron, in which the 3-d metal ions are bound to the oxygen atoms of the carboxyl and phosphonic groups and the tertiary nitrogen atom of the ligand. At the same time, two 5-membered (aminomethylenephosphonic and glycine) and one 6-membered (β-alanine) metallocycles are formed in bis(phosphonomethyl)aminosuccinates. The biological activity of H6BPMAS and its complexes with Ni(II) and Co(II) against non-pathogenic bacterial species of microorganisms Pseudomonas fluorescens and Pseudomonas aureofaciens was studied. The study of the activity of substances was carried out in a liquid sterile Hiss medium. The maximum stimulating effect on the growth of bacterial cultures for the studied compounds was recorded at a concentration of 1 µM in 24 hours after the start of cultivation of microorganisms. The highest growth of microorganisms was recorded for metal complexes (50% Na4[CoBPMAS]·4H2O and 35% Na4[NiBPMAS]·4H2O). The maximum stimulating effect on the growth of bacterial cultures is shown by the Co(II) complex, which is able to initiate the synthesis of one of the most important growth hormones - heteroauxin.Keywords
This publication has 32 references indexed in Scilit:
- Study on a New Synthesis Approach of GlyphosateJournal of Agricultural and Food Chemistry, 2012
- Effect of organogenic materials and bacterial preparations on the biotechnological process of composting and effectiveness of organobacterial fertilizersRussian Agricultural Sciences, 2009
- Recent synthesis of aminophosphonic acids as potential biological importanceAmino Acids, 2009
- New ways to break an old bond: the bacterial carbon–phosphorus hydrolases and their role in biogeochemical phosphorus cyclingEnvironmental Microbiology, 2007
- Influence of glyphosate and its formulation (Roundup®) on the toxicity and bioavailability of metals to Ceriodaphnia dubiaEnvironmental Pollution, 2005
- Optimization of degradation of methylphosphonate — analogue of toxic pollutants with direct CP bond by Escherichia coliProcess Biochemistry, 2001
- Stability and structure of nitrilo(acetate–methylphosphonate) complexes of the alkaline-earth and divalent transition metal ions in aqueous solutionJ. Chem. Soc., Dalton Trans., 2000
- An ATR−FTIR Study of Glyphosate and Its Fe(III) Complex in Aqueous SolutionEnvironmental Science & Technology, 1998
- ORGANOPHOSPHORUS HERBICIDES AND PLANT GROWTH REGULATORS, PART 2. EQUILIBRIUM STUDIES IN AQUEOUS SOLUTION OF THE COMPLEXATION OF TRANSITION METAL(II) IONS BY N-(PHOSPHONOMETHYL)IMINODIACETIC ACID AND RELATED COMPOUNDSJournal of Coordination Chemistry, 1993
- 637. The stability of transition-metal complexesJournal of the Chemical Society, 1953