In Situ Fabrication of Ultrasmall Gold Nanoparticles/2D MOFs Hybrid as Nanozyme for Antibacterial Therapy
- 5 May 2020
- Vol. 16 (23), e2000553
- https://doi.org/10.1002/smll.202000553
Abstract
As one of the common reactive oxygen species, H2O2 has been widely used for combating pathogenic bacterial infections. However, the high dosage of H2O2 can induce undesired damages to normal tissues and delay wound healing. In this regard, peroxidase‐like nanomaterials serve as promising nanozymes, thanks to their positive promotion toward the antibacterial performance of H2O2, while avoiding the toxicity caused by the high concentrations of H2O2. In this work, ultrasmall Au nanoparticles (UsAuNPs) are grown on ultrathin 2D metal–organic frameworks (MOFs) via in situ reduction. The formed UsAuNPs/MOFs hybrid features both the advantages of UsAuNPs and ultrathin 2D MOFs, displaying a remarkable peroxidase‐like activity toward H2O2 decomposition into toxic hydroxyl radicals (·OH). Results show that the as‐prepared UsAuNPs/MOFs nanozyme exhibits excellent antibacterial properties against both Gram‐negative (Escherichia coli) and Gram‐positive (Staphylococcus aureus) bacteria with the assistance of a low dosage of H2O2. Animal experiments indicate that this hybrid material can effectively facilitate wound healing with good biocompatibility. This study reveals the promising potential of a hybrid nanozyme for antibacterial therapy and holds great promise for future clinical applications.Funding Information
- National Basic Research Program of China (2017YFA0206500)
- National Natural Science Foundation of China (21874155, 21635004, 21575163)
- Natural Science Foundation of Jiangsu Province (BK20191316)
- Double First Class University Plan (CPU2018GY25)
- State Key Laboratory of Analytical Chemistry for Life Sciences (SKLACLS1919)
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