A multicolor and ratiometric fluorescent sensing platform for metal ions based on arene–metal-ion contact
Open Access
- 6 July 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Communications Chemistry
- Vol. 4 (1), 1-10
- https://doi.org/10.1038/s42004-021-00541-y
Abstract
Despite continuous and active development of fluorescent metal-ion probes, their molecular design for ratiometric detection is restricted by the limited choice of available sensing mechanisms. Here we present a multicolor and ratiometric fluorescent sensing platform for metal ions based on the interaction between the metal ion and the aromatic ring of a fluorophore (arene–metal-ion, AM, coordination). Our molecular design provided the probes possessing a 1,9-bis(2′-pyridyl)-2,5,8-triazanonane as a flexible metal ion binding unit attached to a tricyclic fluorophore. This architecture allows to sense various metal ions, such as Zn(II), Cu(II), Cd(II), Ag(I), and Hg(II) with emission red-shifts. We showed that this probe design is applicable to a series of tricyclic fluorophores, which allow ratiometric detection of the metal ions from the blue to the near-infrared wavelengths. X-ray crystallography and theoretical calculations indicate that the coordinated metal ion has van der Waals contact with the fluorophore, perturbing the dye’s electronic structure and ring conformation to induce the emission red-shift. A set of the probes was useful for the differential sensing of eight metal ions in a one-pot single titration via principal component analysis. We also demonstrate that a xanthene fluorophore is applicable to the ratiometric imaging of metal ions under live-cell conditions.Keywords
Funding Information
- MEXT | Japan Society for the Promotion of Science (JP17K14518, JP17H06349, JP20H02861)
- Today Science Foundation (Japan) Naito Science Foundation
This publication has 41 references indexed in Scilit:
- A silver complex with an N,S,S-macrocyclic ligand bearing an anthracene pendant arm for optical ethylene monitoringChemical Communications, 2012
- Heavy Metal Toxicity and the EnvironmentPublished by Springer Science and Business Media LLC ,2012
- Fluorescent and colorimetric sensors for detection of lead, cadmium, and mercury ionsChemical Society Reviews, 2011
- A Highly Selective Colorimetric and Fluorescent Probe for Cu2+ and Hg2+ Ions Based on a Distyryl BODIPY with Two Bis(1,2,3‐triazole)amino ReceptorsChemistry – An Asian Journal, 2011
- Development of a Far-Red to Near-Infrared Fluorescence Probe for Calcium Ion and its Application to Multicolor Neuronal ImagingJournal of the American Chemical Society, 2011
- A Turn-On Fluorescent Sensor for Detecting Nickel in Living CellsJournal of the American Chemical Society, 2009
- New acridine derivatives bearing immobilized azacrown or azathiacrown ligand as fluorescent chemosensors for Hg2+ and Cd2+Tetrahedron Letters, 2008
- Chelatoselective fluorescence perturbation in anthrylazamacrocycle conjugate probes. Electrophilic aromatic cadmiationJournal of the American Chemical Society, 1990
- Anthraceno-cryptands: a new class of cation-complexing macrobicyclic fluorophoresJournal of the American Chemical Society, 1989
- Fluorescence quantum yield of oxazine and carbazine laser dyesJournal of Luminescence, 1981