First Serological Evidence of Crimean-Congo Hemorrhagic Fever Virus and Rift Valley Fever Virus in Ruminants in Tunisia
Open Access
- 18 June 2021
- Vol. 10 (6), 769
- https://doi.org/10.3390/pathogens10060769
Abstract
Crimean-Congo hemorrhagic fever virus (CCHFV, Nairoviridae family) and Rift Valley fever virus (RVFV, Phenuiviridae family) are zoonotic vector-borne pathogens with clinical relevance worldwide. Our study aimed to determine seroprevalences of these viruses and potential risk factors among livestock (cattle, sheep, and goats) in Tunisia. Sera were tested for antibodies against CCHFV (n = 879) and RVFV (n = 699) using various enzyme-linked immunosorbent assays (ELISAs) and indirect immunofluorescence assays (IIFA). The overall seroprevalence of IgG antibodies was 8.6% (76/879) and 2.3% (16/699) against CCHFV and RVFV, respectively. For CCHF seropositivity bioclimatic zones and breed were potential risk factors for the three tested animal species; while the season was associated with cattle and sheep seropositivity, tick infestation was associated with cattle and goats seropositivity and age as a risk factor was only associated with cattle seropositivity. Age and season were significantly associated with RVFV seropositivity in sheep. Our results confirm the circulation of CCHFV and RVFV in Tunisia and identified the principal risk factors in ruminants. This knowledge could help to mitigate the risk of ruminant infections and subsequently also human infections.Funding Information
- the German Federal Foreign Office, as part of the German Biosecurity Programme, (XXXXXXXXX)
This publication has 86 references indexed in Scilit:
- Factors associated with IgG positivity to Crimean-Congo hemorrhagic fever virus in the area with the highest seroprevalence in GreeceTicks and Tick-borne Diseases, 2013
- A seroepidemiological survey of Crimean Congo hemorrhagic fever among Cattle in North Kordufan State, SudanVirology Journal, 2013
- Crimean-Congo Hemorrhagic Fever Virus in Ticks from Migratory Birds, Morocco1Emerging Infectious Diseases, 2013
- Culex pipiens, an Experimental Efficient Vector of West Nile and Rift Valley Fever Viruses in the Maghreb RegionPLOS ONE, 2012
- Impact of Climate Trends on Tick-Borne Pathogen TransmissionFrontiers in Physiology, 2012
- Rift Valley and West Nile Virus Antibodies in Camels, North AfricaEmerging Infectious Diseases, 2011
- A newly identified Crimean-Congo hemorrhagic fever virus strain in TurkeyInternational Journal of Infectious Diseases, 2010
- Rift Valley fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and preventionVeterinary Research, 2010
- Molecular epidemiology of Crimean-Congo hemorrhagic fever virus in Turkey: Occurrence of local topotypeVirus Research, 2010
- Crimean-Congo Hemorrhagic Fever Virus Genomics and Global DiversityJournal of Virology, 2006