Meroterpenoids: A Comprehensive Update Insight on Structural Diversity and Biology
Open Access
- 29 June 2021
- journal article
- review article
- Published by MDPI AG in Biomolecules
- Vol. 11 (7), 957
- https://doi.org/10.3390/biom11070957
Abstract
Meroterpenoids are secondary metabolites formed due to mixed biosynthetic pathways which are produced in part from a terpenoid co-substrate. These mixed biosynthetically hybrid compounds are widely produced by bacteria, algae, plants, and animals. Notably amazing chemical diversity is generated among meroterpenoids via a combination of terpenoid scaffolds with polyketides, alkaloids, phenols, and amino acids. This review deals with the isolation, chemical diversity, and biological effects of 452 new meroterpenoids reported from natural sources from January 2016 to December 2020. Most of the meroterpenoids possess antimicrobial, cytotoxic, antioxidant, anti-inflammatory, antiviral, enzyme inhibitory, and immunosupressive effects.Keywords
Funding Information
- This research was funded by the Deanship of Scientific Research at Princess Nourah bint Abdulrahman University through the Fast-track Research Funding Program (-----)
This publication has 134 references indexed in Scilit:
- Anti-diabetic and hypolipidemic effects of Sargassum yezoense in db/db miceBiochemical and Biophysical Research Communications, 2012
- Protective effect of chromene isolated from Sargassum horneri against UV‐A‐induced damage in skin dermal fibroblastsExperimental Dermatology, 2012
- Chemical Diversity of Natural Resources and the Bioactivity of their ConstituentsChimia, 2012
- Cytotoxic Phloroglucinols from the Leaves of Myrtus communisJournal of Natural Products, 2012
- Tuberatolides, Potent FXR Antagonists from the Korean Marine Tunicate Botryllus tuberatusJournal of Natural Products, 2010
- Meroterpenoids produced by fungiNatural Product Reports, 2009
- Biomimetic Synthesis of Tangutorine Following New Biogenetic ProposalsOrganic Letters, 2009
- The evolving role of natural products in drug discoveryNature Reviews Drug Discovery, 2005
- Sargaquinoic acid supports the survival of neuronal PC12D cells in a nerve growth factor-independent mannerEuropean Journal of Pharmacology, 2004
- Natural Products as Sources of New Drugs over the Period 1981−2002Journal of Natural Products, 2003