The Prevalence of Diabetes in Autistic Persons: A Systematic Review
Open Access
- 31 December 2020
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Clinical Practice and Epidemiology in Mental Health
- Vol. 16 (1), 212-225
- https://doi.org/10.2174/1745017902016010212
Abstract
Background: It has been proposed that autistic individuals are at an increased risk of type 1 and type 2 diabetes. Improved understanding of diabetes prevalence in autistic persons will help inform resource allocation for diabetes-related public health measures for this patient group. Objective: To conduct a systematic review of published literature pertaining to type 1 and type 2 diabetes prevalence in autistic individuals, including comparison with their non-autistic peers. Methods: Eligibility criteria included studies investigating the prevalence of diabetes in autistic individuals, as well as having been published in the English language. A systematic search of online databases (MEDLINE, PsycINFO, CINAHL, EMBASE and PubMed) was conducted on 4th April 2020. Additional approaches included the ancestry method, grey literature searches and expert consultation. Studies were qualitatively analysed with reporting quality appraised. Results: 19 eligible studies were identified, 7 of which provided type-specific diabetes prevalence data. Of 15 studies that included a non-autistic control group, 9 reported a higher diabetes prevalence among autistic persons, with a statistically significant difference in 4 studies. Studies demonstrating a higher diabetes prevalence in autistic groups had higher average study population sizes and reporting quality ratings. Conclusion: It is uncertain whether diabetes is significantly more prevalent in autistic persons relative to their non-autistic peers, though larger studies suggest a trend in this direction. Nevertheless, diabetes is a significant public health issue for the autistic community, which may require a tailored approach for identification and management. Prospero database registration number: CRD42019122176.Keywords
This publication has 58 references indexed in Scilit:
- The Co-Morbidity Burden of Children and Young Adults with Autism Spectrum DisordersPLOS ONE, 2012
- People with mild to moderate intellectual disability talking about their diabetes and how they manageJournal of Intellectual Disability Research, 2011
- Inflammatory Markers Are Increased in Youth with Type 1 Diabetes: The SEARCH Case-Control StudyJournal of Clinical Endocrinology & Metabolism, 2010
- The Healthy Lifestyle Change Program: A Pilot of a Community-Based Health Promotion Intervention for Adults with Developmental DisabilitiesAmerican Journal of Preventive Medicine, 2009
- X-Chromosome Gene Dosage and the Risk of Diabetes in Turner SyndromeJournal of Clinical Endocrinology & Metabolism, 2009
- Strengthening the Reporting of Observational Studies in Epidemiology (STROBE): Explanation and ElaborationPLoS Medicine, 2007
- Type 1 Diabetes and Autism Association Seems to Be Linked to the Incidence of DiabetesDiabetes Care, 2006
- Type 1 Diabetes and Autism: Is there a link?Diabetes Care, 2006
- Neuropsychiatric disorders at the presentation of type 2 diabetes mellitus in childrenPediatric Diabetes, 2005