The CLK inhibitor SM08502 induces anti-tumor activity and reduces Wnt pathway gene expression in gastrointestinal cancer models
Open Access
- 24 September 2019
- journal article
- research article
- Published by Elsevier BV in Cancer Letters
- Vol. 473, 186-197
- https://doi.org/10.1016/j.canlet.2019.09.009
Abstract
No abstract availableKeywords
Funding Information
- Samumed, LLC
This publication has 44 references indexed in Scilit:
- Comprehensive molecular characterization of human colon and rectal cancerNature, 2012
- Wnt/β-Catenin Signaling and DiseaseCell, 2012
- Three decades of Wnts: a personal perspective on how a scientific field developedThe EMBO Journal, 2012
- Hallmarks of Cancer: The Next GenerationCell, 2011
- Evaluation of substituted 6-arylquinazolin-4-amines as potent and selective inhibitors of cdc2-like kinases (Clk)Bioorganic & Medicinal Chemistry Letters, 2009
- The SR protein family of splicing factors: master regulators of gene expressionBiochemical Journal, 2008
- Diversity of LEF/TCF action in development and diseaseOncogene, 2006
- WNT and β-catenin signalling: diseases and therapiesNature Reviews Genetics, 2004
- Nuclear speckles: a model for nuclear organellesNature Reviews Molecular Cell Biology, 2003
- The Hallmarks of CancerCell, 2000