The effect on subsequent fracture risk of age, sex, and prior fracture site by recency of prior fracture
- 4 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Osteoporosis International
- Vol. 32 (8), 1547-1555
- https://doi.org/10.1007/s00198-020-05803-4
Abstract
Summary The risk of a recurrent fragility fracture varies by age and sex, as by site and recency of sentinel fracture. Introduction The recency of prior fractures affects subsequent fracture risk. Variable recency may obscure other factors that affect subsequent fracture risk. The aim of this study was to quantify the effect of a sentinel fracture by site, age, and sex where the recency was held constant. Methods The study used data from the Reykjavik Study fracture register that documented prospectively all fractures at all skeletal sites in a large sample of the population of Iceland. Fracture incidence was compared to that of the general population determined at fixed times after a sentinel fracture (humeral, clinical vertebral, forearm, hip, and minor fractures). Outcome fractures comprised a major osteoporotic fracture and hip fracture. Results Sentinel osteoporotic fractures were identified in 9504 men and women. Of these, 3616 individuals sustained a major osteoporotic fracture as the first subsequent fracture, of whom 1799 sustained a hip fracture. Hazard ratios for prior fracture were consistently higher in men than in women and decreased progressively with age. Hazard ratios varied according to the site of sentinel fracture with higher ratios for hip and vertebral fracture than for humerus, forearm, or minor osteoporotic fracture. Conclusion The risk of a recurrent fragility fracture varies by age, sex, and site of sentinel fracture when recency is held constant.Keywords
This publication has 25 references indexed in Scilit:
- Time since prior fracture is a risk modifier for 10-year osteoporotic fracturesJournal of Bone and Mineral Research, 2010
- Hip Fracture Patients at Risk of Second Hip Fracture: A Nationwide Population-Based Cohort Study of 169,145 Cases During 1977–2001Journal of Bone and Mineral Research, 2009
- Clinical subsequent fractures cluster in time after first fracturesAnnals Of The Rheumatic Diseases, 2008
- FRAX™ and the assessment of fracture probability in men and women from the UKOsteoporosis International, 2008
- Inaccuracy in self-report of fractures may underestimate association with health outcomes when compared with medical record based fracture registryEuropean Journal of Epidemiology, 2007
- Evidence From Data Searches and Life-Table Analyses for Gender-Related Differences in Absolute Risk of Hip Fracture After Colles' or Spine Fracture: Colles' Fracture as an Early and Sensitive Marker of Skeletal Fragility in White MenJournal of Bone and Mineral Research, 2004
- A meta-analysis of previous fracture and subsequent fracture riskBone, 2004
- Acute and Long-Term Increase in Fracture Risk after Hospitalization for Vertebral FractureOsteoporosis International, 2001
- Patients with Prior Fractures Have an Increased Risk of Future Fractures: A Summary of the Literature and Statistical SynthesisJournal of Bone and Mineral Research, 2000
- Past fractures indicate increased risk of hip fractureActa Orthopaedica, 1986