Impact of a twelve-year rotavirus vaccine program on acute diarrhea mortality and hospitalization in Brazil: 2006-2018
- 2 June 2020
- journal article
- research article
- Published by Taylor & Francis Ltd in Expert Review of Vaccines
- Vol. 19 (6), 585-593
- https://doi.org/10.1080/14760584.2020.1775081
Abstract
Monitoring the impact of vaccine programs is necessary to identify changes in vaccine efficacy. We report the impact of the 12-year rotavirus vaccine program on diarrhea mortality and hospitalizations and their correlation to socioeconomic indicators. this ecological study describes diarrhea hospitalizations and deaths from 2006 to 2018 in Brazil and correlates rotavirus vaccine coverage, hospitalizations and deaths to socioeconomic indicators and social vulnerability index (SVI) by state and region. Hospitalizations, deaths, and vaccine coverage trends were analyzed using Joinpoint regression models. Associations between hospitalizations, mortality and rotavirus vaccination coverage and socioeconomic and SVI indicators were established using Ordinary Least Square regressions. Rotavirus vaccine coverage remained stable between 2006 and 2018 (annual percentage changes (APC) [95%CI]: 4.4% [−0.3%, 9.2%]). Diarrhea hospitalization rates decreased 52.5% (−5.7% [−7.5%, −3.8%]), from 68.4 to 32.5 hospitalizations per 10,000 children <5 years-old between 2006 and 2018, with significant decreases in diarrhea mortality (−9.8% [−11.2%, −8.5%]). The Northeast region experienced the largest reductions (−13.9% [−15.7%, −12.2%]). Vaccination coverage and diarrhea-mortality were inversely correlated with the SVI. The burden of childhood diarrhea has decreased over an extended period. States with high SVI, but high vaccination coverage had the largest reductions in hospitalizations and deaths.Keywords
This publication has 38 references indexed in Scilit:
- Detection of PCV-2 DNA in stool samples from infants vaccinated with RotaTeq®Human Vaccines & Immunotherapeutics, 2013
- Rotavirus vaccination in developing countriesCurrent Opinion in Virology, 2012
- Impact of rotavirus vaccination on diarrhoea mortality and hospital admissions in BrazilTropical Medicine & International Health, 2011
- Noroviruses as a major cause of acute gastroenteritis in children in Finland, 2009–2010Scandinavian Journal of Infectious Diseases, 2011
- Performance of rotavirus vaccines in developed and developing countriesHuman Vaccines, 2010
- Rotavirus vaccination in northeast Brazil: A laudable intervention, but can it lead to cost-savings?Vaccine, 2010
- Incidence of Rotavirus and All-Cause Diarrhea in Northeast Brazil Following the Introduction of a National Vaccination ProgramGastroenterology, 2009
- Predominance of Rotavirus P[4]G2 in a Vaccinated Population, BrazilEmerging Infectious Diseases, 2007
- Rotavirus and Severe Childhood DiarrheaEmerging Infectious Diseases, 2006
- Small Sample Properties of Tests for Spatial Dependence in Regression Models: Some Further ResultsPublished by Springer Science and Business Media LLC ,1995