Monocyte Recruitment, Specification, and Function in Atherosclerosis
Open Access
- 23 December 2020
- Vol. 10 (1), 15
- https://doi.org/10.3390/cells10010015
Abstract
Atherosclerotic lesions progress through the continued recruitment of circulating blood monocytes that differentiate into macrophages within plaque. Lesion-associated macrophages are the primary immune cells present in plaque, where they take up cholesterol and store lipids in the form of small droplets resulting in a unique morphology termed foam cell. Recent scientific advances have used single-cell gene expression profiling, live-cell imaging, and fate mapping approaches to describe macrophage and monocyte contributions to pro- or anti-inflammatory mechanisms, in addition to functions of motility and proliferation within lesions. Yet, many questions regarding tissue-specific regulation of monocyte-to-macrophage differentiation and the contribution of recruited monocytes at stages of atherosclerotic disease progression remain unknown. In this review, we highlight recent advances regarding the role of monocyte and macrophage dynamics in atherosclerotic disease and identify gaps in knowledge that we hope will allow for advancing therapeutic treatment or prevention strategies for cardiovascular disease.Keywords
Funding Information
- National Heart, Lung, and Blood Institute (HL138163)
- Agence Nationale de la Recherche (ANR-17-CE14-0017-01, ANR-19-ECVD-0005-01)
This publication has 135 references indexed in Scilit:
- The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysisThe Lancet, 2012
- NR4A1 (Nur77) Deletion Polarizes Macrophages Toward an Inflammatory Phenotype and Increases AtherosclerosisCirculation Research, 2012
- Hemoglobin Directs Macrophage Differentiation and Prevents Foam Cell Formation in Human Atherosclerotic PlaquesJournal of the American College of Cardiology, 2012
- The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytesNature Immunology, 2011
- Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated GenesArteriosclerosis, Thrombosis, and Vascular Biology, 2011
- NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystalsNature, 2010
- Regulation of the Migration and Survival of Monocyte Subsets by Chemokine Receptors and Its Relevance to AtherosclerosisArteriosclerosis, Thrombosis, and Vascular Biology, 2009
- Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valvesThe Journal of Experimental Medicine, 2009
- Low-grade chronic inflammation in regions of the normal mouse arterial intima predisposed to atherosclerosisThe Journal of Experimental Medicine, 2006
- Monocyte accumulation in mouse atherogenesis is progressive and proportional to extent of diseaseProceedings of the National Academy of Sciences of the United States of America, 2006