Abstract 4007: Chemopreventive effect of Dioclea reflexa seeds dietary inclusion in experimental colon carcinogenesis

Abstract

The aim of the present study is to evaluate the colon cancer chemopreventive effect of dietary inclusion of Diocleareflexaseed, a popular Nigerian soup condiment in male albino rats following ten weeks of intra-rectal instillation with N-methyl-N-nitrosourea (MNU). Male albino wistar rats, randomly divided into 6 groups of 7 rats each, were fed D. reflexa diatary inclusion at 0%, 2.5%, 5%, and 10% for ten weeks with concomitant of intra-rectal instillation with MNU at MNU at a dose of 1.2mg/rat. At the end of feeding experiment, rats were sacrificed, blood and tissues were collected for biochemical, histological and immunohistochemical analysis. The flavonoids, total polyphenols and fiber content of the experimental diets were also assessed.The level of carcino-embryonic antigen (CEA) and malondialdehyde (MDA) were significantly (pCitation Format: Uju D. Iliemene, Sunday Ene-Ojo Atawodi. Chemopreventive effect of Dioclea reflexa seeds dietary inclusion in experimental colon carcinogenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2018; 2018 Apr 14-18; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2018;78(13 Suppl):Abstract nr 4007.