Sorting Mechanisms for MicroRNAs into Extracellular Vesicles and Their Associated Diseases
Top Cited Papers
Open Access
- 21 April 2020
- Vol. 9 (4), 1044
- https://doi.org/10.3390/cells9041044
Abstract
Extracellular vesicles (EV) are secretory membranous elements used by cells to transport proteins, lipids, mRNAs, and microRNAs (miRNAs). While their existence has been known for many years, only recently has research begun to identify their function in intercellular communication and gene regulation. Importantly, cells have the ability to selectively sort miRNA into EVs for secretion to nearby or distant targets. These mechanisms broadly include RNA-binding proteins such as hnRNPA2B1 and Argonaute-2, but also membranous proteins involved in EV biogenesis such as Caveolin-1 and Neural Sphingomyelinase 2. Moreover, certain disease states have also identified dysregulated EV-miRNA content, shedding light on the potential role of selective sorting in pathogenesis. These pathologies include chronic lung disease, immune response, neuroinflammation, diabetes mellitus, cancer, and heart disease. In this review, we will overview the mechanisms whereby cells selectively sort miRNA into EVs and also outline disease states where EV-miRNAs become dysregulated.Funding Information
- Changwon National University (Changwon National University in 2019~2020)
This publication has 90 references indexed in Scilit:
- Argonaute2 complexes carry a population of circulating microRNAs independent of vesicles in human plasmaProceedings of the National Academy of Sciences of the United States of America, 2011
- Human tumor virus utilizes exosomes for intercellular communicationProceedings of the National Academy of Sciences of the United States of America, 2010
- Secretory Mechanisms and Intercellular Transfer of MicroRNAs in Living CellsJournal of Biological Chemistry, 2010
- Endothelial dysfunction in diabetes mellitus: Molecular mechanisms and clinical implicationsReviews in Endocrine and Metabolic Disorders, 2010
- miR-145 and miR-143 regulate smooth muscle cell fate and plasticityNature, 2009
- Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkersNature, 2008
- MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer (Retracted article. See vol. 175, pg. 192, 2023)Gynecologic Oncology, 2008
- MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1Proceedings of the National Academy of Sciences of the United States of America, 2008
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- Caveolin, a protein component of caveolae membrane coatsCell, 1992