INTRODUCTION AND AIMS: Inflammation, atherosclerosis and oxidative stress are established risk factors for the progression of chronic kidney disease (CKD) and increased cardiovascular (CV) disease (CVD) in these patients. Paraoxonases (PONs) and renin-angiotensin system (RAS) gene polymorphisms have been implicated as potential genetic risk factors for the progression of CKD and CV events in uremic patients. The aim of the study was to investigate the putative role of gene polymorphisms of PON1 (L55M, Q192R), PON2 (S311C), Angiotensinogen (M235T), Angiotensin II type 1 receptor (A1166C) and Angiotensin-Converting Enzyme (ACE ID) on the progression of CKD and CV complications [left ventricular hypertrophy (LVH), events of ischemic heart/cevebrovascular/peripheral vascular disease)] in these patients.