Hyperammonemia syndrome due to Ureaplasma infection after liver-kidney transplant
- 29 April 2020
- journal article
- research article
- Published by Wiley in Transplant Infectious Disease
- Vol. 22 (3), e13298
- https://doi.org/10.1111/tid.13298
Abstract
Hyperammonemia syndrome, with high levels of ammonia and neurologic dysfunction, is a syndrome with historically high mortality that may occur after solid organ transplantation. Recently, this has been associated with infection due to Ureaplasma, mostly following lung transplantation. We describe the first case of hyperammonemia syndrome due to Ureaplasma infection after liver-kidney transplantation. Our patient rapidly recovered after specific antibiotic treatment. It is important to consider these infections in the differential diagnosis for encephalopathy post-transplant, as these organisms often do not grow using routine culture methods and polymerase chain reaction testing is typically required for their detection. This is particularly critical after liver transplantation, where a number of other etiologies may be considered as a cause of hyperammonemia syndrome.Funding Information
- National Heart, Lung, and Blood Institute (T32 HL007287)
- National Institute of Allergy and Infectious Diseases (T32 AI007140‐41)
- National Institute of Diabetes and Digestive and Kidney Diseases (T32 DK007742‐22)
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