Incidence of neurodegenerative and cerebrovascular diseases associated with antihypertensive drug classes
- 7 January 2021
- journal article
- research article
- Published by Royal College of Psychiatrists in The British Journal of Psychiatry
- Vol. 218 (5), 283-285
- https://doi.org/10.1192/bjp.2020.249
Abstract
Antihypertensive drugs (AHTs) are associated with lowered risks of neurodegenerative diseases and stroke. However, the relative risks associated with different AHT classes are unclear. Using an electronic health record network with 34 million eligible patients, we compared rates of these disorders over a 2-year period, in propensity score-matched cohorts of people taking calcium channel blockers (CCBs) compared with those taking other AHT classes. CCBs were associated with a higher incidence of all disorders compared with renin-angiotensin system agents, and a higher incidence of dementia and cerebrovascular disease compared with diuretics. CCBs were associated with a lower incidence of movement disorders and cerebrovascular disease compared with beta-blockers. The data show that AHT classes confer differential risks of neurodegenerative and cerebrovascular diagnoses.Keywords
This publication has 11 references indexed in Scilit:
- Rates of delirium associated with calcium channel blockers compared to diuretics, renin-angiotensin system agents and beta-blockers: An electronic health records network studyJournal of Psychopharmacology, 2020
- β-adrenoreceptors and the risk of Parkinson's diseaseThe Lancet Neurology, 2020
- Antihypertensive medications and risk for incident dementia and Alzheimer's disease: a meta-analysis of individual participant data from prospective cohort studiesThe Lancet Neurology, 2019
- Voltage-gated calcium channel blockers for psychiatric disorders: genomic reappraisalThe British Journal of Psychiatry, 2019
- Within the Brain: The Renin Angiotensin SystemInternational Journal of Molecular Sciences, 2018
- Risk of Parkinson’s Disease in the Users of Antihypertensive Agents: An Evidence from the Meta-Analysis of Observational StudiesJournal of Neurodegenerative Diseases, 2016
- The Propensity ScoreJAMA, 2015
- Long-Term Anti-Hypertensive Therapy and Stroke Prevention: A Meta-AnalysisAmerican Journal of Cardiovascular Drugs, 2015
- Antihypertensive Drugs, Prevention of Cognitive Decline and Dementia: A Systematic Review of Observational Studies, Randomized Controlled Trials and Meta-Analyses, with Discussion of Potential MechanismsCNS Drugs, 2015
- Negative ControlsEpidemiology, 2010