Exosome therapeutics for COVID‐19 and respiratory viruses
Open Access
- 31 January 2021
- Vol. 2 (3), 20200186
- https://doi.org/10.1002/viw.20200186
Abstract
Respiratory viral diseases are a leading cause of mortality in humans. They have proven to drive pandemic risk due to their complex transmission factors and viral evolution. However, the slow production of effective antiviral drugs and vaccines allows for outbreaks of these diseases, emphasizing a critical need for refined antiviral therapeutics. The delivery of exosomes, a naturally secreted extracellular vesicle, yields therapeutic effects for a variety of diseases, including viral infection. Exosomes and viruses utilize similar endosomal sorting pathways and mechanisms, providing exosomes with the potential to serve as a therapeutic that can target, bind, and suppress cellular uptake of various viruses including the novel severe acute respiratory syndrome coronavirus 2. Here, we review the relationship between exosomes and respiratory viruses, describe potential exosome therapeutics for viral infections, and summarize progress toward clinical translation for lung‐derived exosome therapeutics.Keywords
Funding Information
- National Institutes of Health (HL123920, HL137093, HL144002, HL146153, HL147357, HL149940)
- American Heart Association (18TPA34230092, 19EIA34660286)
- National Institutes of Health (HL123920, HL137093, HL144002, HL146153, HL147357, HL149940)
- American Heart Association (18TPA34230092, 19EIA34660286)
This publication has 75 references indexed in Scilit:
- Serum Amyloid P Is a Sialylated Glycoprotein Inhibitor of Influenza A VirusesPLOS ONE, 2013
- Effectiveness of influenza vaccine in aging and older adults: comprehensive analysis of the evidenceClinical Interventions in Aging, 2012
- Vaccine effectiveness in older individuals: What has been learned from the influenza-vaccine experienceAgeing Research Reviews, 2011
- Influenza vaccine responses in older adultsAgeing Research Reviews, 2011
- Exosome-Driven Antigen Transfer for MHC Class II Presentation Facilitated by the Receptor Binding Activity of Influenza HemagglutininThe Journal of Immunology, 2010
- Disabled is a bona fide component of the Abl signaling networkDevelopment, 2010
- Characterization of exosome‐like vesicles released from human tracheobronchial ciliated epithelium: a possible role in innate defenseThe FASEB Journal, 2009
- Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cellsNature, 2007
- Evidence for a protective role of pulmonary surfactant protein D (SP-D) against influenza A viruses.JCI Insight, 1994
- Antibody induction by influenza vaccines in the elderly: a review of the literatureVaccine, 1989