The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells
Open Access
- 1 August 2020
- journal article
- research article
- Published by Oxford University Press (OUP) in Stem Cells Translational Medicine
- Vol. 9 (8), 882-894
- https://doi.org/10.1002/sctm.20-0084
Abstract
A spaceflight has enormous influence on the health of space voyagers due to the combined effects of microgravity and cosmic radiation. Known effects of microgravity (mu g) on cells are changes in differentiation and growth. Considering the commercialization of spaceflight, future space exploration, and long-term manned flights, research focusing on differentiation and growth of stem cells and cancer cells exposed to real (r-) and simulated (s-) mu g is of high interest for regenerative medicine and cancer research. In this review, we focus on platforms to study r- and s-mu g as well as the impact of mu g on cancer stem cells in the field of gastrointestinal cancer, lung cancer, and osteosarcoma. Moreover, we review the current knowledge of different types of stem cells exposed to mu g conditions with regard to differentiation and engineering of cartilage, bone, vasculature, heart, skin, and liver constructs.Funding Information
- Aarhus University
- Deutsches Zentrum für Luft-und Raumfahrt (50WB1923, 50WB1924)
- Aarhus Universitet
This publication has 119 references indexed in Scilit:
- NASA-Approved Rotary Bioreactor Enhances Proliferation of Human Epidermal Stem Cells and Supports Formation of 3D Epidermis-Like StructurePLOS ONE, 2011
- Phenotypic Heterogeneity of Breast Cancer Stem CellsJournal of Oncology, 2011
- Unique Differentiation Profile of Mouse Embryonic Stem Cells in Rotary and Stirred Tank BioreactorsTissue Engineering, Part A, 2010
- Rapid Selection and Proliferation of CD133(+) Cells from Cancer Cell Lines: Chemotherapeutic ImplicationsPLOS ONE, 2010
- LIF-Free Embryonic Stem Cell Culture in Simulated MicrogravityPLOS ONE, 2009
- Epidermal homeostasis: a balancing act of stem cells in the skinNature Reviews Molecular Cell Biology, 2009
- Effects of spaceflight on murine skeletal muscle gene expressionJournal of Applied Physiology, 2009
- Very small embryonic‐like stem cells are present in adult murine organs: ImageStream‐based morphological analysis and distribution studiesCytometry Part A, 2008
- ALDH1 Is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical OutcomeCell Stem Cell, 2007
- Prospective identification of tumorigenic breast cancer cellsProceedings of the National Academy of Sciences of the United States of America, 2003