Association of Red Meat Intake with the Risk of Cardiovascular Mortality in General Japanese Stratified by Kidney Function: NIPPON DATA80
Open Access
- 29 November 2020
- Vol. 12 (12), 3707
- https://doi.org/10.3390/nu12123707
Abstract
The consumption of red meat has been recommended for individuals with reduced kidney function. However, red meat intake was recently suspected to increase cardiovascular disease (CVD) risk. We evaluated the association of red meat intake with CVD mortality risk in Japanese with/without reduced kidney function. Overall, 9112 participants of a Japanese national survey in 1980, aged ≥30 years, were followed for 29 years. Red meat intake was assessed using weighed dietary record. Cox proportional hazards models were used to estimate the hazard ratio (HR) of CVD mortality according to sex-specific tertiles of red meat intake. We also performed stratified analyses with/without reduced kidney function defined as estimated glomerular filtration rate less than 60 mL/min/1.73 m2. Red meat intake was not associated with CVD mortality risk in men and women. In stratified analyses, the HR of the highest compared with the lowest tertile of red meat intake was lower only in women with reduced kidney function (0.67, 95% confidence interval 0.46–0.98). In conclusion, there were no clear associations between red meat intake and CVD mortality risk in Japanese population; however, a higher intake of red meat was associated with lower risk of future CVD mortality in women with reduced kidney function.This publication has 25 references indexed in Scilit:
- Meat intake and cause-specific mortality: a pooled analysis of Asian prospective cohort studiesThe American Journal of Clinical Nutrition, 2013
- Meat consumption in relation to mortality from cardiovascular disease among Japanese men and womenEuropean Journal of Clinical Nutrition, 2012
- Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysisThe Lancet, 2010
- Red and Processed Meat Consumption and Risk of Incident Coronary Heart Disease, Stroke, and Diabetes MellitusCirculation, 2010
- Integration of Data from NIPPON DATA80/90 and National Nutrition Survey in Japan: For Cohort Studies of Representative Japanese on NutritionJournal of Epidemiology, 2010
- Revised Equations for Estimated GFR From Serum Creatinine in JapanAmerican Journal of Kidney Diseases, 2009
- Type 2 diabetes and risk of non-embolic ischaemic stroke in Japanese men and womenDiabetologia, 2004
- Cigarette Smoking as a Risk Factor for Stroke Death in JapanStroke, 2004
- Impact of elevated blood pressure on mortality from all causes, cardiovascular diseases, heart disease and stroke among Japanese: 14 year follow-up of randomly selected population from Japanese — Nippon data 80Journal of Human Hypertension, 2003
- Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials.Arteriosclerosis and Thrombosis: A Journal of Vascular Biology, 1992