Accelerating the reversal of inflammatory pain with NPD1 and its receptor GPR37
- 16 July 2018
- journal article
- editorial
- Published by American Society for Clinical Investigation in JCI Insight
- Vol. 128 (8), 3246-3249
- https://doi.org/10.1172/jci122203
Abstract
Resolution of inflammation is a critical process that is facilitated by specialized proresolving mediators (SPMs). In this issue, Bang et al. show that the G protein-coupled receptor GPR37 is a receptor for one such SPM, neuroprotectin D1. They also show that GPR37 activation in macrophages enhances phagocytosis, shifts cytokine release toward an antiinflammatory profile, and thereby helps to reverse inflammatory pain.This publication has 20 references indexed in Scilit:
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