Influence of HLA-DQ2.5 Dose on Clinical Picture of Unrelated Celiac Disease Patients
Open Access
- 9 December 2020
- Vol. 12 (12), 3775
- https://doi.org/10.3390/nu12123775
Abstract
The clinical phenotype of celiac disease varies considerably among patients and the dosage of HLA-DQ2.5 alleles has been suggested to be a contributing factor. We investigated whether HLA-DQ2.5 allele dosage is associated with distinct clinical parameters at the time of diagnosis and with patients’ response to a gluten-free diet. The final cohort included 605 carefully phenotyped non-related Finnish celiac disease patients grouped as having 0, 1 or 2 copies of HLA-DQ2.5. Clinical data at the time of diagnosis and during gluten-free diet were collected systematically from medical records and supplementary interviews. An increasing HLA-DQ2.5 dose effect was detected for celiac disease antibody positivity at diagnosis (p = 0.021) and for the presence of any first-degree relatives with celiac disease (p = 0.011 and p = 0.031, respectively). Instead, DQ2.5-negative patients were suffering most often from classical symptoms at diagnosis (p = 0.007 between HLA groups). In addition, during follow-up they were most often symptomatic despite a gluten-free diet (p = 0.002 between groups). Our results thus suggest that increasing HLA-DQ2.5 dose only has a minor effect on the clinical picture of celiac disease. However, HLA-DQ2.5-negative patients should not be overlooked in clinical practice and particular attention should be paid to this patient group during gluten-free diet.This publication has 40 references indexed in Scilit:
- Predictors of persistent symptoms and reduced quality of life in treated coeliac disease patients: a large cross-sectional studyBMC Gastroenterology, 2013
- The Oslo definitions for coeliac disease and related termsGut, 2012
- Delay to celiac disease diagnosis and its implications for health-related quality of lifeBMC Gastroenterology, 2011
- Mucosal Recovery and Mortality in Adults With Celiac Disease After Treatment With a Gluten-Free DietThe American Journal of Gastroenterology, 2010
- Impact of symptoms on quality of life before and after diagnosis of coeliac disease: results from a UK population surveyBMC Health Services Research, 2010
- Unwanted incidents during transition of geriatric patients from hospital to home: a prospective observational studyBMC Health Services Research, 2010
- Coeliac diseaseThe Lancet, 2009
- Cost-effective HLA typing with tagging SNPs predicts celiac disease risk haplotypes in the Finnish, Hungarian, and Italian populationsImmunogenetics, 2009
- Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide PolymorphismsPLOS ONE, 2008
- Coeliac disease: an update for pathologistsJournal of Clinical Pathology, 2006