H2A Monoubiquitination Links Glucose Availability to Epigenetic Regulation of the Endoplasmic Reticulum Stress Response and Cancer Cell Death
Open Access
- 9 April 2020
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 80 (11), 2243-2256
- https://doi.org/10.1158/0008-5472.can-19-3580
Abstract
These findings link glucose deprivation and H2A ubiquitination to regulation of the ER stress response in tumor growth and demonstrate pharmacologic susceptibility to inhibition of polycomb and glucose transporters.Other Versions
Funding Information
- NIH NCI (5P50CA070907)
- Department of Defense (KC180131)
- NIH (R01CA181196)
- NIH (R01HG007538, R01CA193466, R01CA228140)
- NCI NIH (P30CA016672)
This publication has 60 references indexed in Scilit:
- Germline mutations in BAP1 predispose to melanocytic tumorsNature Genetics, 2011
- Lkb1 regulates quiescence and metabolic homeostasis of haematopoietic stem cellsNature, 2010
- FoxOs Enforce a Progression Checkpoint to Constrain mTORC1-Activated Renal TumorigenesisCancer Cell, 2010
- Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUBNature, 2010
- DEGseq: an R package for identifying differentially expressed genes from RNA-seq dataBioinformatics, 2009
- Understanding the Warburg Effect: The Metabolic Requirements of Cell ProliferationScience, 2009
- mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilizationProceedings of the National Academy of Sciences of the United States of America, 2008
- Role of Bmi-1 and Ring1A in H2A Ubiquitylation and Hox Gene SilencingMolecular Cell, 2005
- Role of histone H2A ubiquitination in Polycomb silencingNature, 2004
- Reinitiation involving upstream ORFs regulates ATF4 mRNA translation in mammalian cellsProceedings of the National Academy of Sciences of the United States of America, 2004